ELF4 Antibody

Datasheet

Code	CSB-PA857453ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA857453ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA857453ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA857453ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ELF4 Polyclonal antibody

Uniprot No.

Q99607

Target Names

ELF4

Alternative Names

E74-like factor 4 antibody; ELF4 antibody; ELF4_HUMAN antibody; ELFR antibody; ETS-related transcription factor Elf-4 antibody; ETS-related transcription factor Elf4 antibody; MEF antibody; Myeloid Elf-1-like factor antibody; Myeloid Elf1-like factor antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human ETS-related transcription factor Elf-4 protein (1-200AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.

Gene References into Functions

Overall, these data indicate that hypoxia or HIF-1alpha positively regulates MEF expression and function. PMID: 27040637
The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells PMID: 25482012
The p53-MDM2-MEF axis is a feedback mechanism that exquisitely controls the balance of these transcriptional regulators. PMID: 25081543
These studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation. PMID: 23217424
enhanced HDM2 expression induced by mutant NPM1 may have a role in MEF/ELF4-dependent leukemogenesis PMID: 23393136
MEF is involved in PTH suppression of osteoblasts through activating the MKK4/JNK1 pathway and subsequently up-regulating Mab21l1 expression. PMID: 21465527
Loss of ELF4 leads to increased quiescence in bone marrow endothelial cells by the deregulation of cyclin-dependent kinase-4 expression and to enhanced regeneration of sinusoidal blood vessels. PMID: 21350194
Functional dissection of the transactivation mechanisms of the ETS transcription factor MEF PMID: 12151102
MEF is an important regulator of IL-8 expression PMID: 14625302
promyelocytic leukemia protein, but not Sp100, induced the accumulation of MEF in PML nuclear bodies and MEF and PML physically interacted, stimulating MEF transcriptional activity, resulting in the up-regulation of endogenous lysozyme expression. PMID: 14976184
regulation in epithelial cells by Sp1 PMID: 15907486
RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform 1 and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG. PMID: 16303180

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Involvement in disease

A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.

Subcellular Location

Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML.

Protein Families

ETS family

Tissue Specificity

Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cel

Database Links

HGNC: 3319

OMIM: 300775

KEGG: hsa:2000

STRING: 9606.ENSP00000311280

UniGene: Hs.271940

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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