ELOVL2 Antibody

Datasheet

Code	CSB-PA889139LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA889139LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA889139LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ELOVL2 Polyclonal antibody

Uniprot No.

Q9NXB9

Target Names

ELOVL2

Alternative Names

ELOVL2; ELG3; SSC2; Elongation of very long chain fatty acids protein 2; 3-keto acyl-CoA synthase ELOVL2; ELOVL fatty acid elongase 2; ELOVL FA elongase 2; Very long chain 3-ketoacyl-CoA synthase 2; Very long chain 3-oxoacyl-CoA synthase 2

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Elongation of very long chain fatty acids protein 2 protein (91-174AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ELOVL2 Antibody (Product code: CSB-PA889139LA01HU) is Non-conjugated. For ELOVL2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA889139LB01HU	ELOVL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA889139LC01HU	ELOVL2 Antibody, FITC conjugated
Biotin	CSB-PA889139LD01HU	ELOVL2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Gene References into Functions

Results shows that ELOVL2 promoter displays an exceptionally consistent increase in DNA methylation with age in all tissues. PMID: 29848354
ELOVL2 methylation is a marker of cell divisions occurring during human aging PMID: 27672102
common variations not associated with polyunsaturated fatty acid levels in breast milk PMID: 28245901
Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERalpha in Breast Cancer Cells PMID: 27788154
Polymorphisms in the ELOVL2 gene were not associated with the risk of developing allergic disease PMID: 26633493
results show that the ELOVL2 locus provides a very good source of information about human chronological age based on analysis of blood, including bloodstains, and it may constitute a powerful and reliable predictor in future forensic age estimation models PMID: 25450787
we do not found the association between rs3756593 of ELOVL2 gene and acute coronary syndrome in Chinese Han population PMID: 23555103
Methylation of ELOVL2 gene is a new epigenetic marker of age. PMID: 23061750
rs3756963 in ELOVL2 gene may be associated with paranoid schizophrenia. PMID: 21560298
gene interaction analysis showed that the combined genotype of FADS1 rs174556 (T/T) and ELOVL2 rs3756963 (T/T) was weakly associated with coronary artery disease PMID: 21917437

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Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

ELO family, ELOVL2 subfamily

Tissue Specificity

Liver and testis.

Database Links

HGNC: 14416

OMIM: 611814

KEGG: hsa:54898

STRING: 9606.ENSP00000346693

UniGene: Hs.656436

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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