EPHA6 Antibody

Code CSB-PA890673LA01HU
Size US$166
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Image
  • IHC image of CSB-PA890673LA01HU diluted at 1:200 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA890673LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EPHA6 Polyclonal antibody
Uniprot No.
Target Names
EPHA6
Alternative Names
Ehk 2 antibody; EHK-2 antibody; Ehk2 antibody; EPH homology kinase 2 antibody; Eph Receptor A6 antibody; Epha6 antibody; EPHA6_HUMAN antibody; ephrin receptor EphA6 antibody; ephrin type A receptor 6 antibody; Ephrin type-A receptor 6 antibody; Hek12 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ephrin type-A receptor 6 protein (132-279AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The EPHA6 Antibody (Product code: CSB-PA890673LA01HU) is Non-conjugated. For EPHA6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA890673LB01HU EPHA6 Antibody, HRP conjugated ELISA
FITC CSB-PA890673LC01HU EPHA6 Antibody, FITC conjugated
Biotin CSB-PA890673LD01HU EPHA6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Gene References into Functions
  1. The EPHA6 rs4857055 C > T SNP is a novel candidate gene for hypertension in the Korean population. PMID: 29208002
  2. Gene-based analysis identified EPHA6 as the gene most significantly associated with paclitaxel-induced neuropathy...This first study sequencing EPHA genes revealed that low-frequency variants in EPHA6, EPHA5, and EPHA8 contribute to the susceptibility to paclitaxel-induced neuropathy PMID: 27582484
  3. EphA6 mRNA expression is higher in 112 CaP tumor samples compared with benign tissues from 58 benign prostate hyperplasia patients. Positive correlation was identified between EphA6 expression and vascular invasion, neural invasion, PSA level, and TNM staging in CaP cases. PMID: 26041887
  4. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. PMID: 25583493
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20950786
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  7. During development of the retinal vasculature, migration of ligand-bearing astrocytes is slowed along Eph-A6 expression gradient through repellent Eph-A6 - ephrin-A1 and -A4 signaling. PMID: 20011078
  8. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19850283

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Tissue Specificity
Expressed in brain and testis.
Database Links

HGNC: 19296

OMIM: 600066

KEGG: hsa:285220

STRING: 9606.ENSP00000374323

UniGene: Hs.272208

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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