EPHA6 Antibody

Datasheet

Code	CSB-PA890673LA01HU
Size	US$166
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Image	IHC image of CSB-PA890673LA01HU diluted at 1:200 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA890673LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EPHA6 Polyclonal antibody

Uniprot No.

Q9UF33

Target Names

EPHA6

Alternative Names

Ehk 2 antibody; EHK-2 antibody; Ehk2 antibody; EPH homology kinase 2 antibody; Eph Receptor A6 antibody; Epha6 antibody; EPHA6_HUMAN antibody; ephrin receptor EphA6 antibody; ephrin type A receptor 6 antibody; Ephrin type-A receptor 6 antibody; Hek12 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ephrin type-A receptor 6 protein (132-279AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The EPHA6 Antibody (Product code: CSB-PA890673LA01HU) is Non-conjugated. For EPHA6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA890673LB01HU	EPHA6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA890673LC01HU	EPHA6 Antibody, FITC conjugated
Biotin	CSB-PA890673LD01HU	EPHA6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

Gene References into Functions

The EPHA6 rs4857055 C > T SNP is a novel candidate gene for hypertension in the Korean population. PMID: 29208002
Gene-based analysis identified EPHA6 as the gene most significantly associated with paclitaxel-induced neuropathy...This first study sequencing EPHA genes revealed that low-frequency variants in EPHA6, EPHA5, and EPHA8 contribute to the susceptibility to paclitaxel-induced neuropathy PMID: 27582484
EphA6 mRNA expression is higher in 112 CaP tumor samples compared with benign tissues from 58 benign prostate hyperplasia patients. Positive correlation was identified between EphA6 expression and vascular invasion, neural invasion, PSA level, and TNM staging in CaP cases. PMID: 26041887
Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. PMID: 25583493
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20950786
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
During development of the retinal vasculature, migration of ligand-bearing astrocytes is slowed along Eph-A6 expression gradient through repellent Eph-A6 - ephrin-A1 and -A4 signaling. PMID: 20011078
Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19850283

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily

Tissue Specificity

Expressed in brain and testis.

Database Links

HGNC: 19296

OMIM: 600066

KEGG: hsa:285220

STRING: 9606.ENSP00000374323

UniGene: Hs.272208

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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