ERAP2 Antibody, FITC conjugated

Code CSB-PA007761LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ERAP2 Polyclonal antibody
Uniprot No.
Target Names
ERAP2
Alternative Names
ERAP2 antibody; LRAPEndoplasmic reticulum aminopeptidase 2 antibody; EC 3.4.11.- antibody; Leukocyte-derived arginine aminopeptidase antibody; L-RAP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Endoplasmic reticulum aminopeptidase 2 protein (406-522AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
Gene References into Functions
  1. this study shows the association of ERAP2 single nucleotide polymorphism and its haplotypes with psoriasis vulgaris, and its dependence on the presence or absence of the HLA-C*06:02 allele and age at disease onset PMID: 29183862
  2. These results indicated that the ERAP gene may play a critical role in HCV chronicity in this Chinese Han population PMID: 29037997
  3. ERAP2 deficiency causes increased MHC class I free heavy chain expression and up-regulation of the unfolded protein response pathway in anklyosing spondylitis. PMID: 28029742
  4. ERAP-2 significantly influences the B*27:05-bound peptidome by destroying some ligands and decreasing the abundance of many more ligands with N-terminal basic residues, while increasing the abundance of nonamers. The former effects are best explained by direct ERAP-2 trimming. The effects on peptide length might be attributed to ERAP-2-induced activation of ERAP-1 trimming. These data support the notion of a peptide-media PMID: 27110896
  5. study reveals fine-mapped AID risk variants that act as eQTLs with ERAP2 in thymus PMID: 27829666
  6. Increased expression of ERAP2 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis. PMID: 27384923
  7. ERAP2 is associated with ankylosing spondylitis in HLA-B27 positive and HLA-B27 negative patients. PMID: 25917849
  8. ERAP2 might be associated with CLNM in PTMC. PMID: 26148615
  9. ERAP2 variation does not have a significant effect on PBMC intracellular and cell surface HLA-class I expression and heavy chain formation, markers of ER stress or inflammatory cytokine production. PMID: 26088389
  10. The risk allele of the polymorphism near ERAP2 is strongly associated with birdshot chorioretinopathy. PMID: 24957906
  11. ERAP2 haplotype A is correlated with resistance to HIV-1 infection, possibly secondarily to its effect on antigen processing and presentation. PMID: 23435305
  12. The association and co-localization of ERAP2 and EpCAM at the surface of breast cancer cells is a unique and novel finding that provides new ideas on EpCAM processing and on how antigen presentation may be regulated in cancer. PMID: 23988446
  13. Generation and destruction of antigenic peptides by endoplasmic reticulum resident aminopeptidases ERAP1 and ERAP2 have been shown in the last few years to be important for correct functioning and regulation of the adaptive immune response. PMID: 23545452
  14. The common ERAP2 single nucleotide polymorphism rs2549782 that codes for amino acid variation Asp392Lys leads to alterations in both the activity and the specificity of the enzyme. PMID: 22837489
  15. crystals of ERAP2 belonged to an orthorhombic space group and diffracted anisotropically to 3.3 A resolution in the best direction on an in-house X-ray source PMID: 22505422
  16. The molecular structure of glycosylated human ERAP2 has been determined to 3.08 A resolution by molecular replacement using ERAP1 as a search model and refined. PMID: 22106953
  17. assessed frequency of rs2248374 SNP in ERAP2 in ankylosing spondylitis (AS) cases and controls and found no association with AS PMID: 21719416
  18. strong evidence that ERAP2 plays a role in the development of preeclampsia PMID: 21569342
  19. ERAP2 was found to have bimodal expression in human skeletal muscle tissue. PMID: 21299892
  20. Data show that the differences between the ERAP2 splice forms provide important insights into the potential mechanism for the action of selection. PMID: 20976248
  21. ERAP2, which encodes an aminopeptidase, did not show preferential parent-of-origin expression, but rather, cis-acting nonimprinted differential allelic control PMID: 18369178
  22. Novel preeclampsia risk locus, ERAP2, in a region of known genetic linkage to this pregnancy-specific disorder. PMID: 19578876
  23. Dramatic genetic effect on LRAP expression. PMID: 17129607

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Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein Families
Peptidase M1 family
Tissue Specificity
Ubiquitously expressed. Highly expressed in spleen and leukocytes.
Database Links

HGNC: 29499

OMIM: 609497

KEGG: hsa:64167

STRING: 9606.ENSP00000400376

UniGene: Hs.482910

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