Exendin-4 Antibody

Datasheet
Code CSB-PA853477
Size US$299
Uniprot No. P26349
Immunogen Synthetic peptide of Heloderma suspectum Exendin 4
Raised in Rabbit
Species Reactivity Heloderma suspectum
Tested Applications ELISA;ELISA:1:1000-1:2000
Relevance Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion. It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias Exendin 4
Immunogen Species Heloderma suspectum (Gila monster)
Protocols ELISA Protocol
Target Names N/A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
Subcellular Location Secreted
Protein Families Glucagon family
Tissue Specificity Expressed by the venom gland.

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