FAM49B Antibody

Code CSB-PA873658LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FAM49B Polyclonal antibody
Uniprot No.
Target Names
FAM49B
Alternative Names
BM 009 antibody; FA49B_HUMAN antibody; Fam49b antibody; Family with sequence similarity 49; member B antibody; L1 antibody; Protein FAM49B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein FAM49B protein (1-324AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The FAM49B Antibody (Product code: CSB-PA873658LA01HU) is Non-conjugated. For FAM49B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA873658LB01HU FAM49B Antibody, HRP conjugated ELISA
FITC CSB-PA873658LC01HU FAM49B Antibody, FITC conjugated
Biotin CSB-PA873658LD01HU FAM49B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization. Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry. Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress.
Gene References into Functions
  1. FAM49B inhibits T cell activation by repressing Rac activity and modulating cytoskeleton reorganization. PMID: 29632189
  2. Three proteins-matrix metalloproteinase-9, neutrophil elastase, and FAM49B-were significantly lower in abundance in samples from women with endometriosis. PMID: 25284053
  3. FAM49B is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
Subcellular Location
Membrane; Lipid-anchor. Mitochondrion.
Protein Families
FAM49 family
Database Links

HGNC: 25216

KEGG: hsa:51571

STRING: 9606.ENSP00000384880

UniGene: Hs.126941

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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