FANCF Antibody

1. LOH in FA genes appears to be a common feature of head and neck squamous cell carcinomas development seen here in 57% of patients and other mutation types may increase this mutation frequency. We suggest larger patient cohorts would be needed to test the observed association of LOH in FANCF and patient survival comprehensively PMID: 28440438
2. we report three patients who illustrate the clinical variability within the FA-F group. This analysis suggests a more severe phenotype for those with the common c.484_485delCT mutation. PMID: 27714961
3. CpG island methylation of FANCF gene promoter region is strongly associated with the susceptibility and clinicopathologic features of epithelial ovarian cancer. PMID: 26507869
4. careful examination of three electively aborted fetuses in one family and one affected girl in the other indicated an association of the FANCF loss-of-function mutation with a severe phenotype characterized by multiple malformations PMID: 26033879
5. Data suggest that the Fanconi anemia group F protein/BRCA1/2 proteins pathway may be a new target to reverse adriamycin (ADR) resistance in leukemia treatment. PMID: 24996439
6. Silencing of FANCF enhanced the antiproliferative effect of ADM in OVCAR3 cells. PMID: 23440494
7. FANCF methylation is a rare event in Japanese primary invasive breast cancer. PMID: 19813073
8. Data identify the gene encoding Fanconi F (FANCF) as an ICSBP target gene. PMID: 19801548
9. inactivation of the FANC-BRCA pathway is relatively common in solid tumors and may be related to tobacco and alcohol exposure and survival PMID: 14647419
10. Inactivation of genes in the FA-BRCA pathway by epigenetic alterations have been found in a high proportion of cervix cancer patients, suggesting a major role for this pathway in the development of cervical cancer. PMID: 15126331
11. FANCF acts as a flexible adaptor protein that plays a key role in the proper assembly of the FA core complex. PMID: 15262960
12. results showed that FANCF methylation regulates the expression of FANCF at both mRNA and protein levels; methylation-induced inactivation of FANCF plays an important role in the occurrence of ovarian cancers via disrupting the FA-BRCA pathway PMID: 16418574
13. human FANCF protein has specific structural components that function in the assembly of a DNA damage signaling complex PMID: 17082180
14. FANCF methylation was rare in breast tumors PMID: 17932744
15. This study does not support methylation-dependent silencing of FANCF as a mechanism of sensitisation to platinum-based chemotherapy in ovarian cancer. PMID: 18414472

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HGNC: 3587

OMIM: 603467

KEGG: hsa:2188

STRING: 9606.ENSP00000330875

UniGene: Hs.632151