FBXO9 Antibody

Code CSB-PA891719LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA891719LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA891719LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FBXO9 Polyclonal antibody
Uniprot No.
Target Names
FBXO9
Alternative Names
Cross-immune reaction antigen 1 antibody; dJ341E18.2 antibody; DKFZp434C0118 antibody; F-box only protein 9 antibody; Fbp24 antibody; FBX09 antibody; FBX9 antibody; FBX9_HUMAN antibody; Fbxo9 antibody; KIAA0936 antibody; NY REN 57 antibody; OTTHUMP00000016628 antibody; OTTHUMP00000016629 antibody; OTTHUMP00000214588 antibody; Renal carcinoma antigen NY-REN-57 antibody; VCIA1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human F-box only protein 9 protein (13-111AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The FBXO9 Antibody (Product code: CSB-PA891719LA01HU) is Non-conjugated. For FBXO9 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA891719LB01HU FBXO9 Antibody, HRP conjugated ELISA
FITC CSB-PA891719LC01HU FBXO9 Antibody, FITC conjugated
Biotin CSB-PA891719LD01HU FBXO9 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
Subcellular Location
Cytoplasm.
Database Links

HGNC: 13588

OMIM: 609091

KEGG: hsa:26268

STRING: 9606.ENSP00000244426

UniGene: Hs.216653

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