FBXW10 Antibody, FITC conjugated

Code CSB-PA726395LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FBXW10 Polyclonal antibody
Uniprot No.
Target Names
FBXW10
Alternative Names
FBXW10 antibody; F-box/WD repeat-containing protein 10 antibody; F-box and WD-40 domain-containing protein 10 antibody; Ubiquitin ligase-specificity factor antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human F-box/WD repeat-containing protein 10 protein (701-1000AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
Gene References into Functions
  1. O-GlcNAcylation is involved in the regulation of ubiquitination-related genes including FBXW10 PMID: 23899520
  2. Mislocalized lamins can induce ubiquitin-mediated proteasomal degradation of certain HP1 isoforms by activation of FBXW10, a member of the F-box family of proteins that is involved in E3 ubiquitin ligase activity. PMID: 20498703
Database Links

HGNC: 1211

OMIM: 611679

KEGG: hsa:10517

STRING: 9606.ENSP00000379026

UniGene: Hs.592128

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