FBXW4 Antibody

Code CSB-PA008525ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008525ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA008525ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FBXW4 Polyclonal antibody
Uniprot No.
Target Names
FBXW4
Alternative Names
FBXW4 antibody; FBW4 antibody; SHFM3 antibody; F-box/WD repeat-containing protein 4 antibody; Dactylin antibody; F-box and WD-40 domain-containing protein 4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human F-box/WD repeat-containing protein 4 protein (143-412AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
Gene References into Functions
  1. biochemical characterization of the novel F-box and WD40 containing protein, FBXW4 PMID: 23658844
  2. a complex rearrangement associated with a approximately 0.5 Mb tandem duplication ion containing a disrupted extra copy of the DACTYLIN gene and the entire LBX1 and beta-TRCP genes. PMID: 12913067
  3. results indicate that genomic rearrangement of SHFM3 is rare among non-syndromic SHFM patients and emphasize the importance of screening for genomic rearrangements even in sporadic cases of SHFM PMID: 16235095
  4. Genomic rearrangements involving the SHFM3 locus at chromosome 10q24 is associated with syndromic and non-syndromic split-hand/foot malformation PMID: 16761290
Involvement in disease
Split-hand/foot malformation 3 (SHFM3)
Tissue Specificity
Expressed in brain, kidney, lung and liver.
Database Links

HGNC: 10847

OMIM: 246560

KEGG: hsa:6468

STRING: 9606.ENSP00000373698

UniGene: Hs.500822

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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