FCER1A Antibody

Code CSB-PA008532GA01HU
Size US$685
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Product Details

Uniprot No. P12319
Target Names FCER1A
Alternative Names Fc epsilon RI alpha antibody; Fc epsilon RI alpha chain antibody; Fc epsilon RI alpha-chain antibody; Fc fragment of IgE high affinity I receptor for alpha polypeptide antibody; Fc fragment of IgE; high affinity I; receptor for; alpha subunit antibody; Fc fragment of IgE; high affinity I; receptor for; alpha polypeptide antibody; Fc IgE receptor alpha polypeptide antibody; Fc IgE receptor; alpha chain antibody; Fc IgE receptor; alpha polypeptide antibody; Fc of IgE high affinity I receptor for alpha polypeptide antibody; Fc-epsilon RI-alpha antibody; FCE 1A antibody; FCE1A antibody; FCER 1A antibody; Fcer1a antibody; FCERA_HUMAN antibody; FceRI alpha antibody; FcERI antibody; high affinity IgE receptor antibody; High affinity immunoglobulin epsilon receptor alpha subunit antibody; high affinity immunoglobulin epsilon receptor alpha-subunit antibody; High affinity immunoglobulin epsilon receptor subunit alpha antibody; IgE Fc receptor alpha subunit antibody; IgE Fc receptor subunit alpha antibody; Immunoglobulin E receptor high affinity of mast cells alpha polypeptide antibody; immunoglobulin E receptor; high-affinity; of mast cells; alpha polypeptide antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Human FCER1A
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Gene References into Functions
  1. Patient stratification revealed a significant association (P < 0.05) of rs2427827 SNP with high IgE level Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) patients. Nonetheless, we found no SNP associated with low serum IgE level patients. SNP (rs2427827) in the FcvarepsilonR1alpha gene region and high IgE levels may confer susceptibility to CRSwNP in north Indian population. PMID: 29243845
  2. Data show that each IgE Fc is targeted by two single-domain antibodies (sdabs) having an epitope largely distinct from the FcepsilonRI binding site but overlapping significantly with the CD23-binding site. PMID: 29295972
  3. Autoreactive CD4(+) T cells that target FcepsilonRIalpha were detected in most subjects with chronic spontaneous urticaria, with a cytokine secretion profile more typical of a TH1-cell response. Our findings suggest that measurement of T-cell as well as autoantibody responses to FcepsilonRIalpha could improve diagnostic accuracy in subjects with chronic spontaneous urticaria . PMID: 27417022
  4. Our results suggest that IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108, four SNPs with significant sole effect on asthma, interact to confer a higher risk for the disease in Chinese Han children. PMID: 26613553
  5. F-AFE containing anti-allergic phytochemicals, including arctigenin, inhibited the activation of the FceRI receptor induced by the antigenIgE complex PMID: 26707911
  6. IgG2 and IgG3 are involved in recruiting CD32 to inhibit activation of FcepsilonRI in human basophils. PMID: 26774660
  7. Asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) Fc epsilon RI(+) blood mast cell progenitors than asthmatics with normal lung function. PMID: 26626992
  8. SNPs of FcepsilonR1alpha promoter region may be used as disease markers for IgE-mediated allergic inflammation caused by Dermatophagoides pteronyssinus. PMID: 25923080
  9. FcepsilonRI alpha-chain is an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand. PMID: 25713122
  10. Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation PMID: 26136426
  11. These data suggest that rs2298805 might be associated with risk for Chronic urticaria and the therapeutic efficacy of nonsedating H1-antihistamines in Chinese patients PMID: 25412950
  12. FCER2 polymorphism rs3760687 affects moderately elevated total serum IgE levels, especially in the absence of homozygosity for the risk allele of FCER1A SNP rs2427837. PMID: 24354852
  13. Data indicate that antigen (Ag) targeting to FcepsilonRI inhibits the development of Ag-specific T cell immunity and induces T cell tolerance. PMID: 24610015
  14. FCER1A expressing dendritic cells and monocytes but not basophils, significantly contribute to serum hIgE clearance. PMID: 24569373
  15. elevated levels of surface-bound proteins on cord blood basophils is associated with maternal allergy PMID: 23980848
  16. Genetic polymorphism is associated with IgE levels in asthmatics in Germany PMID: 23725541
  17. Overexpression of miR-142-3p enhances FcepsilonRI-mediated degranulation. PMID: 24361879
  18. We assayed the genotype and allele frequencies of rs2298804 (251 A>G) in the FCER1A gene, in patients with Systemic Lupus Erythematosus in a Chinese Han population and found a significant difference for both the AG genotype and the G allele PMID: 23621092
  19. no association between SNP in the FCER1A gene region and serum total IgE level in Chinese allergic rhinitis patients PMID: 22800345
  20. Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children PMID: 22384272
  21. Mutation in IgE receptor is associated with mast-cell leukemia. PMID: 22173243
  22. Linkage disequilibrium and the distribution of haplotypes for two identified human FCER1A 3'-UTR polymorphisms and several previously reported 5'-flanking region and 5'-UTR variants in Japanese and Poles, is described. PMID: 21725845
  23. genetic polymorphisms in the promoter region is associated with atopic dermatitis in a Han Chinese population PMID: 22222815
  24. increased FcepsilonRI expression on alveolar mast cells is a novel disease-specific feature of allergic asthma. PMID: 21958156
  25. Data show that the developed method allows for comparative analysis of sFcepsilonRI levels in health and disease. PMID: 21903095
  26. There were no significant relationships between FcepsilonRI and atopic dermatitis, although there were trends towards an association between the 66T>C (rs2251746) polymorphism and total serum IgE levels. PMID: 21738338
  27. FcepsilonRI transgene on dendritic cells drives the cascade of pathogenic reactions linking the initial allergen capture by IgE with subsequent T helper (Th)2-dominated T cell responses and the development of late-phase allergic tissue inflammation. PMID: 21622859
  28. The crystal structure of IgE bound to FcepsilonRI is determined. PMID: 21516097
  29. SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population PMID: 21209833
  30. Data indicate that although results rather show the lack of an association between FCER1A rs41264475 mutation and atopic dermatitis, they suggest that its minor allele can predispose to the concomitant asthma in AD patients. PMID: 21216468
  31. The ability of four synthetic and sequence-specific RNA interfering antisense oligodeoxynucleotides (AS-ODNs) to reduce the expression of FcepsilonRIalpha gene in granulocytes of allergy sufferers in vitro, was investigated. PMID: 19697153
  32. Secretagogue stimulation results in an increase in the immature p46 form of FcepsilonRIalpha due to reversal of degradative pathways rather than increased synthesis of FcepsilonRIalpha. PMID: 20664273
  33. FCER1A variants by themselves and in combination influence IgE levels and act synergistically to influence eczema risk. PMID: 20028371
  34. Data suggest a contribution of Fc epsilonRI alpha and gamma chains either to immunosurveillance or pathophysiology of the intestinal epithelium. PMID: 20126404
  35. FcRIalpha gene variants are involved in the pathogenesis of IBD. PMID: 20163202
  36. Data show that atopic dermatitis patients with the FCER1A -315CT/TT genotype tended to have higher total serum IgE levels. PMID: 20141544
  37. Glucose can augment Fc epsilon RI-mediated mast cell activation, particularly the degranulation response and LTC(4) secretion after prolonged culture of mast cells with high-glucose medium. PMID: 20523060
  38. counterregulation of FcepsilonRI and TLR-7 pathways exists in Plasmacytoid dendritic cells PMID: 20410486
  39. genetic polymorphismn, mutational screening and asthma association studies; review PMID: 18726713
  40. SP downregulated expression of FcepsilonRI in a concentration dependent manner; the effect was mediated by the neurokinin-1 receptor and resulted in reduced mast cell activation. PMID: 20117843
  41. Expression of FcepsilonRI was significantly elevated on respiratory tract dendritic cells (RTDC) from atopic as compared to nonatopic patients. PMID: 19385959
  42. homozygosity for the C allele of FcepsilonRI alpha chain variant is associated with lower IgE levels PMID: 12070183
  43. Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. PMID: 12200378
  44. Transcriptional regulation of the high affinity IgE receptor alpha-chain gene. PMID: 12217383
  45. Efficient folding of the FcepsilonRI alpha-chain membrane-proximal domain D2 depends on the presence of the N-terminal domain D1. PMID: 12270716
  46. mast cells modulate the immune system following TLR4-mediated activation and FcepsilonRI aggregation PMID: 12855579
  47. In clinically uninvolved skin, Langerhans' cell-surface Fc epsilon RI expression is not only linked to atopic dermatitis but is also generally associated with allergic disease. PMID: 12897750
  48. T/C polymorphism in Fc epsilon RI alpha-chain promoter at nucleotide position -66 is associated with allergic diseases in a Japanese population. PMID: 12902495
  49. Fc epsilon RI-mediated calcium flux (dependent on PLC gamma 1) leads to degranulation of mast cells independent of PI 3-kinase PMID: 13129935
  50. Results indicate that interleukin-4, together with recombinant human stem cell factor, can induce T cell maturation from cord blood progenitor cells, and that IL-4 increased the expression of FcepsilonRI on fetal liver mast cells. PMID: 14746805
  51. a combination of FcepsilonRI and Kit-mediated signals and transcriptional processes were required for optimal physiologic responses of human mast cells to antigen PMID: 15217825
  52. FcepsilonRI+ on dendretic cells is finely modified by the TGF-beta1 concentration in the microenvironment and could be of primary relevance in the context of atopic diseases. PMID: 15373772
  53. Amphiregulin was secreted by human mast cells after aggregation of FcepsilonRI. PMID: 15696081
  54. conformational change in IgE is required to allow both Cepsilon3 domains to bind to FcepsilonRI PMID: 15743766
  55. Cross-linking of the high affinity IgE receptor (Fc epsilon RI) induces mobilization of free calcium in airway smooth muscle cells, one of the critical signals to trigger smooth muscle contraction. PMID: 16081836
  56. TLR9- and FcepsilonRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expression. PMID: 16237063
  57. microarray data identify Lyn as a negative regulator in Ag-stimulated bone marrow-derived mast cells of the expression of genes linked to FcepsilonRI signaling and also to the response pathways that lead to allergy and asthma PMID: 16339523
  58. IgE receptor alpha-chain transport is controlled by a multicomponent intracellular retention signal PMID: 16459334
  59. Soluble FcepsilonRIalpha is shown to display characteristic properties of a catalyst for the folding of Cepsilon3, with the rate of Cepsilon3 folding being dependent on the concentration of the receptor. PMID: 16563391
  60. This and other evidence discussed in this review provide an emerging view of FcepsilonR/IgE network as a critical modulator of ASM cell function in allergic asthma. PMID: 16581830
  61. The stalk region of the Fc epsilon receptor I alpha-chain is the portion of the molecule regulating the stability of FceRI on the cell surface. PMID: 16709862
  62. Genetic variability of FCER1A exon 2A was evaluated and the -12663 A>G FCER1A polymorphism frequency was determined in a representative sample of whites. PMID: 17165285
  63. the plasma membrane distributions of IGE receptor and its cross-talk with formyl peptide receptor PMID: 17267694
  64. results replicate finding of higher -344CC genotype frequency in asthmatic patients with lower serum IgE levels; association suggests functional role of -344TT genotype, leading to elevated IgE levels in allergic patients by means of an unknown mechanism PMID: 17521040
  65. Using an anti-FcepsilonRI alpha-chain mAb, it was shown that IgE- & high-affinity receptor for IgE (FcepsilonRI)-dependent stimuli can upregulate basophil CD69 expression. PMID: 17541278
  66. In caucasian, allergic patients, FCER1A and FCER1B polymorphisms showed an additive association with total serum IgE levels. PMID: 17686114
  67. A conservative protein sequence of the high-affinity IgE receptor subunit a, despite its variations in non-coding flanking regions, suggests functional importance of the receptor in the development of adaptive immunity. PMID: 17883736
  68. Within regulatory elements of FCER1A some common single nucleotide polymorphisms have functional associations which do not confer susceptibility to allergic diseases, but rather modulate serum concentrations of immunoglobulin E (IgE). [Review] PMID: 17965580
  69. Whereas FcvarepsilonRI required Lyn and Syk for NTAL phosphorylation, Kit appeared to directly phosphorylate NTAL PMID: 17993265
  70. Siglec-8 ligation was shown to inhibit beta-hexosaminidase release and Ca++ flux triggered through FcepsilonRI in RBL-2H3 cells transfected with full-length human Siglec-8. PMID: 18036650
  71. These findings show that the extracellular domain of the type I transmembrane protein Fc epsilon RI alpha plays a role in Fc epsilon RI intracellular processing and expression at the cell surface. PMID: 18179824
  72. Canine C epsilon3 is the only domain essential for binding to canine or human Fc epsilon RI alpha, species specific residues in canine Cepsilon2 and C epsilon4 inhibit dissociation of the ligand from the receptor. PMID: 18187193
  73. IgG autoantibodies to IgE or its receptor, Fc epsilonRIalpha, have been detected in chronic idiopathic urticaria (CIU) patients. CIU patients' basophils display distinct altered Fc epsilonRIalpha-mediated degranulation. PMID: 18356810
  74. enhanced Fc epsilonRI expression in human neutrophils from allergic asthmatics during the pollen season can make them more susceptible to the biological effects of IgE PMID: 18382690
  75. study investigated allelic frequencies, haplotypes and genetic linkage measures of the novel Ex1A polymorphisms in Japanese and compared them with those recalculated in Polish subjects PMID: 18394141
  76. A -315 single nucleotide polymorphism (SNP) significantly affects IgE receptor type I (FcERI) alpha-chain promoter activity and expression level of Fc epsilon RI on basophils by binding different transcription factors to the SNP site. PMID: 18523286
  77. The FCER1G-237A>G and FCERIA-344C>T polymorphisms may contribute to the development of AIA in a Korean population. PMID: 18595682
  78. polymorphisms genotyped in total of 88 Caucasians of the Polish origin were shown to be rare, with minor allele frequencies of 0.023 (-778C) and 0.017 (-673A PMID: 18680511
  79. Functional variants in the gene were strongly associated with total IgE levels in all cohorts. PMID: 18846228
  80. positive and negative regulators of FcepsilonRI have roles in mast cell activation [review] PMID: 19082920
  81. IgG autoantibodies with specificity for the FcepsilonRIalpha detected in 30% of patients with chronic urticaria; also described in patients with asthma PMID: 19141351
  82. progressive immobilization of Fc epsilon RI during aggregation was sensitive to syk or actin polymerization inhibition. Therefore, desensitization is also not dependent on receptor immobilization. PMID: 19150851
  83. mast cells are able to store TSLP intracellularly and to produce TSLP following aggregation of FcepsilonRI in the presence of IL-4 PMID: 19164348
  84. Common variants in FCER1A strongly influence basal IgE production independently from environmental stimuli. PMID: 19245427
  85. Results show that neutrophil FcepsilonRI expression is not regulated by serum IgE. PMID: 19359220
  86. The differential phosphorylation profiles of protein tyrosine residues in the resulting mast cells with or without FcepsilonRI aggregation were examined. PMID: 19494509
  87. This observation suggests a functional relantionship of FcepsilonRI in the regulation of autoimmune response observed in Wegener's granulomatosis. PMID: 19514647
  88. FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding. PMID: 19685047
  89. Reconstitution of the immunoglobulin (Ig)E effect in the humanized Fc epsilon type I high affinity receptor alpha chain knockin mouse represents the first demonstration of human IgE antitumor adjuvanticity. PMID: 19748979
  90. x ray crystallography of multiple crystal forms PMID: 11531339

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Subcellular Location Cell membrane, Single-pass type I membrane protein
Database Links

HGNC: 3609

OMIM: 147140

KEGG: hsa:2205

STRING: 9606.ENSP00000357097

UniGene: Hs.897

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