FCHO1 Antibody, FITC conjugated

Code CSB-PA008546LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FCHO1 Polyclonal antibody
Uniprot No.
Target Names
FCHO1
Alternative Names
FCHO1 antibody; KIAA0290F-BAR domain only protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human F-BAR domain only protein 1 protein (45-180AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
Gene References into Functions
  1. Fcho1/2Eps15/RAP-2 ternary complexes to facilitate conformational activation of AP-2 by the Fcho1/2 interdomain linker to promote AP-2 cargo engagement. PMID: 27237791
  2. The central linker of FCHO proteins acts as an allosteric regulator of the prime endocytic adaptor, AP-2. PMID: 25303365
  3. show that the mu-homology domain of FCHO1/2 represents an endocytic interaction hub PMID: 22484487
  4. study reports FCHo1/2 were required for plasma membrane clathrin-coated vesicle (CCV) budding & marked sites of CCV formation PMID: 20448150
  5. Involved in clathrin-coated vesicle formation. PMID: 17617719

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Subcellular Location
Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.
Protein Families
FCHO family
Database Links

HGNC: 29002

OMIM: 613437

KEGG: hsa:23149

STRING: 9606.ENSP00000252771

UniGene: Hs.96485

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