FCRL2 Antibody

Datasheet

Code	CSB-PA853454ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA853454ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA853454ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FCRL2 Polyclonal antibody

Uniprot No.

Q96LA5

Target Names

FCRL2

Alternative Names

CD307b antibody; Fc receptor homolog 2 antibody; Fc receptor like protein 2 antibody; Fc receptor-like protein 2 antibody; FcR-like protein 2 antibody; FcRH2 antibody; FCRL 2 antibody; FcRL2 antibody; FCRL2_HUMAN antibody; IFGP family protein 4 antibody; IFGP4 antibody; Immunoglobulin receptor translocation associated 4 protein antibody; Immunoglobulin receptor translocation-associated protein 4 antibody; IRTA4 antibody; SH2 domain containing phosphatase anchor protein 1 antibody; SH2 domain-containing phosphatase anchor protein 1 antibody; SPAP1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Fc receptor-like protein 2 protein (20-100AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May have an regulatory role in normal and neoplastic B cell development.

Gene References into Functions

decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to rheumatoid arthritis inflammatory processes. PMID: 27193470
FCRL2 overexpression in B cells from Hashimoto and Graves disease patients compared to normal subjects. PMID: 25738996
a negative immunomodulatory function for FCRL2 in the regulation of memory B cells. PMID: 21068405
B-CLL patients with high FCRL2 expression had a significantly longer treatment-free survival & overall survival than those with low FCRL2. PMID: 19682311
FCRL2 has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in chronic lymphocytic leukemia. PMID: 18314442
Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia. PMID: 18704934
Down-regulation of FCRL2 is associated with acute lymphoblastic leukemia. PMID: 18802695

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone

Database Links

HGNC: 14875

OMIM: 606509

KEGG: hsa:79368

STRING: 9606.ENSP00000355157

UniGene: Hs.437393

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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