FMNL1 Antibody

1. FMNL1 contributes to leukemogenesis and could act in part through Rac1 regulation. PMID: 23801653
2. constitutively activated form of FMNL1 (FMNL1gamma) induces localization of AHNAK1 to the cell membrane. PMID: 23182705
3. Results suggest that macrophage coiling phagocytosis is a complex process involving several actin nucleation/regulatory factors. They also point specifically to the formins mDia1 and FMNL1 as novel regulators of spirochete uptake by human immune cells. PMID: 23460512
4. after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics. PMID: 21148482
5. Our data suggest that FRL1 is responsible for modifying actin at the macrophage podosome and may be involved in actin cytoskeleton dynamics during adhesion and migration within tissues. PMID: 20617518
6. Results describe N-myristoylation as a regulative mechanism of FMNL1 responsible for membrane trafficking potentially involved in a diversity of polarized processes of hematopoietic lineage-derived cells. PMID: 19815554
7. Western blot analysis demonstrated that the protein encoded by this gene is overexpressed in lymphoid malignancies, cancer cell lines and peripheral blood leukocyte from chronic lymphocytic leukemia (CLL) patients. PMID: 14592423

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HGNC: 1212

OMIM: 604656

KEGG: hsa:752

STRING: 9606.ENSP00000329219

UniGene: Hs.100217