FNTA Antibody

Datasheet

Code	CSB-PA064938
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA064938(FNTA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA064938(FNTA Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P49354

Target Names

FNTA

Alternative Names

CAAX farnesyltransferase alpha subunit antibody; CAAX farnesyltransferase subunit alpha antibody; EC 2.5.1.58 antibody; EC 2.5.1.59 antibody; Farnesyl protein transferase alpha subunit antibody; Farnesyltransferase CAAX box alpha antibody; Farnesyltransferase; CAAX box; alpha antibody; Fnta antibody; FNTA_HUMAN antibody; FPTA antibody; FTase alpha antibody; FTase-alpha antibody; GGTase I alpha antibody; GGTase-I-alpha antibody; MGC99680 antibody; OTTHUMP00000229206 antibody; OTTHUMP00000229262 antibody; PGGT1A antibody; Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit antibody; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha antibody; Protein prenyltransferase alpha subunit repeat containing 2 antibody; PTAR2 antibody; Ras proteins prenyltransferase alpha antibody; Ras proteins prenyltransferase subunit alpha antibody; Type I protein geranyl geranyltransferase alpha subunit antibody; Type I protein geranyl-geranyltransferase subunit alpha antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Fusion protein of Human FNTA

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Gene References into Functions

These findings collectively suggest that the combination of farnesyltransferase inhibitors and gamma-secretase inhibitors is a promising therapeutic strategy for glioblastoma through selectively targeting the cancer stem cell subpopulation. PMID: 29198824
Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit PMID: 28948621
our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability PMID: 22160308
Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site. PMID: 15451670
Geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an inhibitor of protein prenylation, elicited significant inhibition of glucose-stimulated insulin secretion from INS 832/13 islet cells. PMID: 17192483
FTase, via its tubulin-association, is a critical upstream regulator of HDAC6 activity PMID: 19228685

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Protein Families

Protein prenyltransferase subunit alpha family

Database Links

HGNC: 3782

OMIM: 134635

KEGG: hsa:2339

STRING: 9606.ENSP00000303423

UniGene: Hs.370312

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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