FOXA3 Antibody

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Datasheet

Code	CSB-PA008796LA01HU
Size	US$166
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Image	IHC image of CSB-PA008796LA01HU diluted at 1:700 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FOXA3 Polyclonal antibody

Uniprot No.

P55318

Target Names

FOXA3

Alternative Names

FKHH3 antibody; Fork head-related protein FKH H3 antibody; forkhead box A3 antibody; Forkhead box protein A3 antibody; Foxa3 antibody; FOXA3_HUMAN antibody; hepatic nuclear factor-3-beta antibody; hepatocyte nuclear factor 3 antibody; hepatocyte nuclear factor 3 gamma antibody; Hepatocyte nuclear factor 3-gamma antibody; HNF-3-gamma antibody; HNF-3G antibody; HNF3B antibody; HNF3G antibody; TCF-3G antibody; TCF3G antibody; Transcription factor 3G antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Hepatocyte nuclear factor 3-gamma protein (220-336AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The FOXA3 Antibody (Product code: CSB-PA008796LA01HU) is Non-conjugated. For FOXA3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA008796LB01HU	FOXA3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA008796LC01HU	FOXA3 Antibody, FITC conjugated
Biotin	CSB-PA008796LD01HU	FOXA3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC1 promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.

Gene References into Functions

Our study identified novel FOXA3 variants and mutations, assessed the adipogenic capacity of two novel missense alterations in vitro and demonstrated for the first time the associations between FOXA3 SNP rs28666870 with metabolic phenotypes in humans. PMID: 25672906
Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity in asthma and chronic obstructive pulmonary disease. PMID: 24392884
In obese subjects, FOXA3 is differentially expressed in visceral and subcutaneous adipose depots. PMID: 23798556
low caloric intake decreases the production of intracellular reactive oxygen species and suppresses endothelial cells senescence through promoting HNF3gamma binging to NOX4 promoter region and inhibiting NOX4 gene expression induced by up-regulated HNF3gamma PMID: 22659429

Subcellular Location

Nucleus.

Tissue Specificity

Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined.

Database Links

HGNC: 5023

OMIM: 602295

KEGG: hsa:3171

STRING: 9606.ENSP00000304004

UniGene: Hs.36137

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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