FPR2 Antibody

Code CSB-PA594474
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA594474(FPR2 Antibody) at dilution 1/17, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
FPR2
Alternative Names
FPR2; FPRH1; FPRL1; LXA4R; N-formyl peptide receptor 2; FMLP-related receptor I; FMLP-R-I; Formyl peptide receptor-like 1; HM63; Lipoxin A4 receptor; LXA4 receptor; RFP
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of Human FPR2
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:10000
IHC 1:20-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. Acts as a receptor for humanin.
Gene References into Functions
  1. FPR2 promotes invasion and metastasis of gastric cancer cells and predicts the prognosis of patients. PMID: 28600569
  2. Phenol-soluble modulin (PSM) peptides from highly pathogenic Staphylococcus aureus are efficient ligands for FPR2. PMID: 28855276
  3. these results show that FPR2signaling interferes with the endosomal trafficking of influenza viruses and provides, for the first time, the proof of concept that monoclonal antibodies directed against FPR2 inhibit virus replication PMID: 29738458
  4. serum amyloid A (SAA) may stimulate the migration of SKOV3 cells through FPR2. The present study suggested that FPR2 promoted the invasion and metastasis of Epithelial ovarian cancer (EOC) and it could be a prognostic marker for EOC. PMID: 29039544
  5. plasma levels higher in preeclamptic women than in nonpregnant and normotensive pregnant women, and similar between nonpregnant and normotensive pregnant women PMID: 27179254
  6. Our findings provide evidence for defective LXA4 generation and FPR2/ALXR expression that, associated with increased LTB4, might be involved in a reduction in the ability of inhaled corticosteroids to impair control of airway inflammation in children with SA. PMID: 26971688
  7. These data show that viral replication and IAV pathogenesis depend on FPR2 signaling and suggest that FPR2 may be a promising novel strategy to treat influenza. PMID: 27034344
  8. Changes in the histone acetylation/methylation status enhanced FPR2 signaling in response to LXA4 during inflammation process. PMID: 27424221
  9. a novel FPR2 agonist, the proteolytically stable alpha-peptide/beta-peptoid hybrid Lau-((S)-Aoc)-(Lys-betaNphe)6-NH2 (F2M2), showing comparable potency in activating human and mouse neutrophils by inducing a rise in intracellular Ca(2+) concentration and assembly of the superoxide-generating NADPH oxidase. PMID: 27422818
  10. We conclude that ANX-A1 is an important regulator of mast cell reactivity to compound 48/80 exerting a negative feedback effect through a mechanism that depends at least partly on the FPR receptor PMID: 26803520
  11. pro-inflammatory stimuli lead to FPR2/ALX expression while LXA4 induces an anti-inflammatory response PMID: 26248046
  12. Data show that the purinergic receptor P2Y2 (P2Y2R) pepducin activates neutrophils through formyl peptide receptor 2 (FPR2), and ATP is turned into an activating agonist through a receptor cross-talk mechanism that involves both FPR2 and P2Y2R. PMID: 26996596
  13. Lipoxin A4 may have a role in preventing metabolic syndrome in a middle-aged Chinese population PMID: 26565966
  14. Serum amyloid A1alpha induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils. PMID: 26297794
  15. significant increase in expression of mRNA in placenta from women with pre-eclampsia PMID: 24960456
  16. ANXA1 may contribute to the regulation of tumor growth and metastasis through paracrine mechanisms that are mediated by FPR2/ALX PMID: 25490767
  17. Role of formyl peptide receptor 2 in homing of endothelial progenitor cells and therapeutic angiogenesis PMID: 25304660
  18. Expression of FPR2/ALX was analysed in 127 carotid atherosclerotic lesions and revealed that this receptor was expressed on macrophages, smooth muscle cells, and endothelial cells. PMID: 25341894
  19. There was an excessive maternal inflammatory response in preeclampsia. LXA4, ALX-R, and NF-kappaB p65 may be involved in the disease process ofpreeclampsia. PMID: 25864260
  20. Molecular determinants required for modulation of endocytic recycling in the anti-apoptotic function of FPR2/ALX. PMID: 25326384
  21. A stable peptidomimetic inhibited the activation of human neutrophils via direct interaction with FPR2. PMID: 25462815
  22. The effects of diclofenac on the incidence of pancreatitis following endoscopic retrograde cholangiopancreatography via lipoxin A4 and resolvin D1 and E1 levels is reported. PMID: 25030943
  23. Uteroglobin is a possible ligand of the lipoxin receptor and it may have a role in inhibiting serum amyloid A-driven inflammation PMID: 24782597
  24. The MAT-1 can induce chemotaxis specifically using FPR2, a receptor found on the surface of monocytes, macrophages and neutrophils. PMID: 24617769
  25. We also found that human mast cells expressed the N-formyl-peptide receptor 1 (FPRL1) receptor and FPRL1-specific inhibitor affected pleurocidin-mediated activation of mast cell. PMID: 23839065
  26. LXA decreased IgM and IgG production on activated human B cells through ALX/FPR2-dependent signaling. PMID: 24166736
  27. Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands. PMID: 24285541
  28. The H. pylori-derived peptide Hp(2-20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-beta, two key mediators of tissue remodelling. PMID: 24067461
  29. FPR2 is expressed in minor salivary glands with and without Sjogren's syndrome. PMID: 24259417
  30. lipoxin A4 may play a role in the resolution of upper airway inflammation. A low concentration of lipoxin A4 may be involved in chronic inflammation of the upper airways. PMID: 24358628
  31. Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. PMID: 24108355
  32. FPR2 is not activated by lipoxin (LX)A; the molecular mechanism by which LXA functions still needs to be identified. PMID: 23643932
  33. Cross-talk between FPR2 and HGF receptor in human prostate epithelial cells. PMID: 23583448
  34. FPR2 is upregulated in peripheral blood mononuclear cells from patients with atherosclerosis. PMID: 23500463
  35. FPRL1 is responsible for TLR3 signaling induced by LL-37-poly(I:C). PMID: 23386607
  36. It was concluded that the ability of FPR2 to discriminate between the enantiomers is the consequence of the arrangement of three asymmetric hydrophobic subpockets at the main orthosteric FPR2 binding site. PMID: 23219934
  37. Most of the analyzed Enterococcus faecium but only sporadic Enterococcus faecalis strains released FPR2/ALX-stimulating molecules leading to neutrophil calcium ion fluxes, chemotaxis, and complement receptor upregulation. PMID: 22768166
  38. No evidence for the involvement of the lipoxin A4 receptor (FPR2/ALX ) gene in the susceptibility to coronary artery disease PMID: 22734147
  39. N-terminal region was dispensable for AnxA1-induced FPR2/ALX down-regulation in both the homologous and heterologous desensitization modes. PMID: 22610094
  40. Neutrophil activity induced by a cell-permeable peptide derived from the third intracellular loop of FPR2 is dose-dependently inhibited by membrane-permeable peptide inhibitor PBP10. PMID: 22706076
  41. Single-nucleotide polymorphism located in the intron of FPR2 is related to aspirin hypersensitivity in asthmatics. PMID: 22377711
  42. Results provide information on FPR2/ALX transcriptional regulation and evidence of mutations that affect FPR2/ALX transcription. PMID: 22131270
  43. These data support a model in which FPR2/ALX plays a role in chemotaxis and activation of monocytes; however, they also suggest that its function in resident tissue macrophages is limited. PMID: 22246625
  44. FPR2 has an appreciable pleiotropic regulator role in tumor immunoediting PMID: 21499310
  45. SAA up-regulates PTX3 production via FPRL1 significantly, and thus, contributes to the inflammatory pathogenesis of atherosclerosis. PMID: 21465531
  46. N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation. PMID: 21543323
  47. Data sugget the existence of an endogenous network in anti-inflammation centered on PMN AnxA1 and activated by selective FPR2/ALX agonists. PMID: 21398608
  48. the innate immune system may be able to respond in different ways to pathogenic or innocuous staphylococci by monitoring the presence of phenol-soluble modulins via FPR2. PMID: 21183593
  49. Data suggest that bacteria induce glial cell activation and rCRAMP expression via FPRL1 and MARCO, and these receptors contribute to the host defence against infection. PMID: 21299846
  50. The results indicate that SAA stimulates FPR2-mediated activation of p38 MAPK and JNK, which are independent of a pertussis toxin-sensitive G-protein and are essential for SAA-induced CCL2 production. PMID: 20177146

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Detected in lung, bone marrow, neutrophils, spleen and testis.
Database Links

HGNC: 3827

OMIM: 136538

KEGG: hsa:2358

STRING: 9606.ENSP00000340191

UniGene: Hs.99855

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