FREM2 Antibody, Biotin conjugated

1. FREM2 is thus proposed as a novel GB biomarker and a putative biomarker of glioblastoma stem cells. Both FREM2 and SPRY1 are expressed on the surface of the GB cells, while SPRY1 alone was found overexpressed in the cytosol of non-malignant astrocytes. PMID: 29734672
2. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. PMID: 24700879
3. Amplification of the FREM2 gene is associated with mesenchymal differentiation in gliosarcoma. PMID: 22538188
4. Heterozygous missense mutations in FREM2 cause non-syndromic congenital abnormalities of the kidney and urinary tract in humans. PMID: 21900877
5. report on 2 fetuses affected by Fraser syndrome (FS); a homozygous IVS14 + 1G -- A mutation in FREM2 was indentified; present report provides additional evidence that FS may be caused by complete or near-complete lack or loss of function of FREM2 protein PMID: 18203166
6. 1 new mutation in FREM2 was identified in families with Fraser syndrome. PMID: 18671281

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HGNC: 25396

OMIM: 608945

KEGG: hsa:341640

STRING: 9606.ENSP00000280481

UniGene: Hs.253994