FSCN2 Antibody

1. diffuse expression in 82% of undifferentiated/dedifferentiated endometrial carcinomas PMID: 28272224
2. Tax-mediated transcriptional induction of Fascin requires NF-kappaB- and TRR-dependent promoter activation, and a promoter-independent, but PP2-sensitive signaling pathway. PMID: 26363219
3. the serum fascin level is an effective indicator of tumor aggressiveness, and that it plays an important role in the prognosis of NSCLC, particularly for non-distant metastatic patients. PMID: 24070574
4. Data indicate the specific contribution of fascin and cortactin during invadopodium formation. PMID: 24414419
5. The filopodium: a stable structure with highly regulated repetitive cycles of elongation and persistence depending on the actin cross-linker fascin PMID: 21975552
6. Fascin expression predicts survival after potentially curative resection of node-positive colon cancer. PMID: 20410808
7. The 208delG mutation in the FSCN2 gene produces not only autosomal dominant retinitis pigmentosa but also ADMD (autosomal dominant macular degeneration) PMID: 14609921
8. The photoreceptor-specific FSCN2 gene showed a relatively high number of sequence variations. PMID: 16280978
9. The 208delG mutation in FSCN2 is not associated with hereditary retinal degeneration in the Chinese individuals examined. PMID: 17251446
10. Real-time PCR-based genotyping method developed here is useful for investigations of allelic asymmetries within genomic regions with variations found in retinitis pigmentosa and retinl degeneration. PMID: 18450588
11. In ovarian tumors fascin is associated with certain features of increased tumor aggressiveness. PMID: 18498068
12. Higher fascin scores correlated positively with tumor differentiation of esophageal SqCC. Significantly worse prognosis in patients with high scores of fascin, poor differentiation, T4 stage, positive for lymph node metastasis and distant metastasis PMID: 19207554
13. expression may play an essential role in regulation of progression of oral squamous cell carcinoma and contributes to the event of epithelial-mesenchymal transition in the early aggressiveness of OSCC PMID: 19473443

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HGNC: 3960

OMIM: 607643

KEGG: hsa:25794

STRING: 9606.ENSP00000334665

UniGene: Hs.118555