GABRA6 Antibody, HRP conjugated

Code CSB-PA623078LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GABRA6 Polyclonal antibody
Uniprot No.
Target Names
GABRA6
Alternative Names
GABA A antibody; GABA A Receptor alpha 6 polypeptide antibody; GABA A receptor alpha 6 antibody; GABA A receptor subunit alpha 6 antibody; GABA subunit A receptor alpha 6 antibody; GABA(A) receptor subunit alpha-6 antibody; GABRA 6 antibody; GABRA6 antibody; Gamma aminobutyric acid A receptor alpha 6 antibody; Gamma aminobutyric acid GABA A receptor alpha 6 antibody; Gamma aminobutyric acid receptor subunit alpha 6 antibody; Gamma-aminobutyric acid receptor subunit alpha-6 antibody; GBRA6_HUMAN antibody; MGC116903 antibody; MGC116904 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Gamma-aminobutyric acid receptor subunit alpha-6 protein (20-242AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene References into Functions
  1. TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotional signals PMID: 25974322
  2. NOS3, GABRA6, child abuse, neighborhood crime Gene x Gene, Environment x Environment, and Gene x Environment interactions are associated with different patterns of respiratory sinus arrhythmia reactivity. PMID: 26535938
  3. The gene-gene interaction at two loci involving GABRA6 and Synapsin II revealed a significant association for development of idiopathic generalized epilepsy. PMID: 25088614
  4. genetic association study in Chinese Han population: Data suggest an SNP in GABRA6 (rs3219151) is associated with decreased predisposition to schizophrenia via alteration of miroRNA binding to target in 3-prime-untranslated region of GABRA6 mRNA. PMID: 23332465
  5. GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy and cause neuronal disinhibition and increase in seizures via a reduction of alphabetagamma and alphabetadelta receptor function and expression PMID: 21930603
  6. Part of the interindividual differences observed for anxiety traits measured by the Harm Avoidance dimension could be explained by the GABRA6 gene variability. PMID: 21902679
  7. significant involvement of alpha (GABRA6) and beta (GABRB2) subunits of GABA(A) receptor in epilepsy susceptibility in north Indian population PMID: 21420396
  8. studies have found prefrontal cortical GABA(A) receptor alpha subunit alterations in schizophrenia PMID: 20100621
  9. These findings support a role for the serotonin transporter and GABA(A) alpha6 subunit in depression-related traits. PMID: 14744464
  10. The T1521C polymorphism in the GABRA6 gene is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress. PMID: 15197399
  11. GABRA6 expression is regulated by NFI in cerebellar granule neurons PMID: 15466411
  12. Findings support a role for GABRA6 (Pro385Ser) in perceived parenting. PMID: 16402352
  13. Polymorphism not associated with panic disorder. PMID: 17167337
  14. Chinese patients with certain psychiatric characteristics and GABRA6 heterozygosity are probably predisposed to functional heartburn PMID: 17295876
  15. The T allele of the 1519T>C GABA(A)alpha6 gene may be one of the modulating factors associated with changes in craving for alcohol and food during treatment of patients with alcohol dependence. PMID: 18616664
  16. Significant matching effects were found for polymorphisms at the DRD2, GABRA6 and GABRB2 gene. In addition, a trend was found for the OPRM1 polymorphism. PMID: 19523047

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Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA6 sub-subfamily
Database Links

HGNC: 4080

OMIM: 137143

KEGG: hsa:2559

STRING: 9606.ENSP00000274545

UniGene: Hs.90791

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