GCHFR Antibody

Code CSB-PA009318LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA009318LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA009318LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GCHFR Polyclonal antibody
Uniprot No.
Target Names
GCHFR
Alternative Names
GCHFR antibody; GFRP antibody; GFRP_HUMAN antibody; GTP cyclohydrolase 1 feedback regulatory protein antibody; GTP cyclohydrolase I feedback regulator antibody; GTP cyclohydrolase I feedback regulatory protein antibody; HsT16933 antibody; MGC138467 antibody; MGC138469 antibody; p35 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human GTP cyclohydrolase 1 feedback regulatory protein (11-55AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GCHFR Antibody (Product code: CSB-PA009318LA01HU) is Non-conjugated. For GCHFR Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009318LB01HU GCHFR Antibody, HRP conjugated ELISA
FITC CSB-PA009318LC01HU GCHFR Antibody, FITC conjugated
Biotin CSB-PA009318LD01HU GCHFR Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
Gene References into Functions
  1. homozygous individuals for the TT haplotype were less likely to respond to the SSRI fluoxetine than to the nortriptyline suggesting a biological process through which GCHFR promoter variants might influence antidepressant response. PMID: 20351752
  2. Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein PMID: 11799107
  3. allosteric regulation of GTPCH-I activity in the cardiovascular system maybe an important mechanism regulating BH4 levels through GTPCH-I feedback regulatory protein signaling PMID: 15649650
  4. GFRP/GTPCHI axis functions in epidermal keratinocytes and melanocytes in the cytosol and nucleus. PMID: 16778797
  5. GCH1 mutations in Japanese patients with DYT5 dystonia. In some of them, the GCH1 enzyme activity was proved to be impaired. PMID: 17101830
  6. The co-expression of GTP cyclohydrolase I (GCHI) with tyrosine hydroxylase (TH) indicates that TH is indeed active in human neurosecretory neurons. PMID: 17135716
  7. Demonstrate role for GFRP in regulating iNOS-mediated NO synthesis and suggest that the allosteric regulation of GTP-CH1 activity by GFRP may be an important mechanism regulating BH(4) and NO levels in vivo. PMID: 18372436
  8. crystal structure PMID: 11580249

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Subcellular Location
Nucleus. Nucleus membrane. Cytoplasm, cytosol.
Protein Families
GFRP family
Tissue Specificity
In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
Database Links

HGNC: 4194

OMIM: 602437

KEGG: hsa:2644

STRING: 9606.ENSP00000260447

UniGene: Hs.631717

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