Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GCSAM Polyclonal antibody

Uniprot No.

Q8N6F7

Target Names

GCSAM

Alternative Names

GCAT2 antibody; Gcet antibody; GCET2 germinal center expressed transcript 2 antibody; GCET2 germinal centre expressed transcript 2 antibody; Gcsam antibody; GCSAM_HUMAN antibody; Germinal center associated lymphoma antibody; Germinal center associated lymphoma protein antibody; Germinal center B cell associated protein 2 antibody; Germinal center B-cell-expressed transcript 2 protein antibody; Germinal center expressed transcript 2 antibody; Germinal center-associated lymphoma protein antibody; Germinal center-associated signaling and motility protein antibody; Germinal centre associated lymphoma antibody; Germinal centre associated lymphoma protein antibody; Germinal centre B cell associated protein 2 antibody; Germinal centre expressed transcript 2 antibody; hGAL antibody; M17 antibody; M17 L antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Germinal center-associated signaling and motility protein (1-178AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.

Gene References into Functions

Diagnostic Utility of the Germinal Center-associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms. PMID: 25203428
These findings further elucidate the growing and complex role of HGAL in B-cell biology and suggest that membrane-bound and cytoplasmic HGAL protein differently regulates distinct biological processes. PMID: 25381061
HGAL and LMO2 may be useful adjuncts in the identification of follicular lymphoma of the nongastric gastrointestinal tract. PMID: 22914613
the germinal centre protein human germinal centre-associated lymphoma regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B-cell lymphoproliferation. PMID: 23299888
HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma. PMID: 22743653
Immunostaining for HGAL was more frequently positive than that for BCL6 and CD10 in follicular lymphomas PMID: 21988858
Data suggest that both HGAL and LMO2 are directly regulated by the transcription repressor PRDM1--overexpression of PRDM1 down-regulates HGAL and LMO2; PRDM1 directly binds to promoters of both HGAL and LMO2 and represses genetic transcription. PMID: 21722313
necessary for germinal center maintenance and confining B-cells to the germinal center microenvironment PMID: 21475040
show that HGAL increases the binding of myosin to F-actin and inhibits the ability of myosin to translocate actin by reducing the maximal velocity of myosin head/actin movement PMID: 21447067
HGAL is sensitive and specific marker for detecting follicular lymphoma in nodal and extranodal sites PMID: 21502424
molecular mechanism underlying the inhibitory effects of germinal center-specific HGAL protein on the motility of GC-derived lymphoma cells PMID: 20844236
Our results show that HGAL and LMO2 are sensitive markers for follicular lymphoma diagnosis. PMID: 20697248
Study confirms and validates findings of a correlation between HGAL expression and outcome in classical HL. PMID: 19883310
gene is induced by IL4 and expression strongly predicts survival in diffuse large B-cell lymphoma PMID: 12509382
Results report the cloning of germinal center B-cell expressed transcripts 1 and 2 (GCET1 and 2), and show that both are expressed in follicular lymphoma and diffuse large B-cell lymphoma with germinal center B-cell differentiation PMID: 12819018
The restricted expression and germinal center specificity of HGAL protein suggest that it may have an important role in the diagnosis of specific lymphomas PMID: 15677569
HGAL is involved in negative regulation of lymphocyte migration, thus constraining lymphocytes to the germinal center PMID: 17823310
The correlation of HGAL expression with the germinal center B-cell phenotype demonstrates the role of this marker in the classification of cutaneous large B-cell lymphomas PMID: 18264083
results report the cloning of HGAL, a germinal center its expression pattern in normal tissues and hematologic malignancies, its induction by IL4, and the prognostic significance of its expression in predicting survival in diffuse large B-cell lymphoma PMID: 12509382

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Subcellular Location

Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.

Tissue Specificity

Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.

Database Links

HGNC: 20253

OMIM: 607792

KEGG: hsa:257144

STRING: 9606.ENSP00000419485

UniGene: Hs.49614