GGA3 Antibody

1. In the absence of GGA3, integrins are increasingly retained inside the cell, traffic toward the perinuclear lysosomal compartment and their degradation is enhanced. PMID: 26935970
2. This work identifies GGA3 as a key player in a novel DXXLL-mediated endosomal sorting machinery that targets TrkA to the plasma membrane, where it prolongs the activation of Akt signaling and survival responses. PMID: 26446845
3. role of GGA3 in the cell surface export of alpha2B-adrenergic receptor PMID: 26811329
4. GGA3 is involved in the cellular processes relevant for Alzheimer's disease pathogenesis. PMID: 23970038
5. Subcellular fractionation of Alzheimer's disease cortex with low levels of Golgi-localized GGA proteins shows an alteration of beta-secretase distribution and extensive co-localization with amyloid beta precursor protein APP. PMID: 21440067
6. GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery PMID: 20484053
7. structures of the VHS domain of human GGA3 complexed with signals from both mannose-6-phosphate receptors PMID: 11859375
8. These results indicate that GGA3-S is predominantly expressed in human tissues except the brain and in cell lines. PMID: 12810073
9. RNAi of GGA3 expression results in accumulation of the cation-independent mannose 6-phosphate receptor and internalized epidermal growth factor (EGF) within enlarged early endosomes. This perturbation impairs the degradation of internalized EGF. PMID: 15039775
10. found that the human GGA3 protein GAT domain contains two ubiquitin binding motifs that bind to the same surface of ubiquitin PMID: 15494413
11. GGA proteins funstion with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface. PMID: 15615712
12. crystal structure of the GAT domain PMID: 15701688
13. GGA3, becomes transiently phosphorylated upon activation of the epidermal growth factor (EGF) receptor. (GGA3) PMID: 16135791
14. CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported. PMID: 16977309
15. ubiquitin binding and ubiquitylation of GGA3-GAT domain are mutually inseparable through a ubiquitin ligase activity of hVPS18 PMID: 16996030
16. We have elucidated a GGA3-dependent mechanism regulating BACE levels and beta-secretase activity. This mechanism may explain increased cerebral levels of BACE and Abeta following cerebral ischemia and existing in AD. PMID: 17553422
17. seladin-1 downregulation increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis PMID: 19815556

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HGNC: 17079

OMIM: 606006

KEGG: hsa:23163

STRING: 9606.ENSP00000245541

UniGene: Hs.87726