GLMN Antibody

Datasheet

Code	CSB-PA170354
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA170354(GLMN Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA170354(GLMN Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q92990

Target Names

GLMN

Alternative Names

FAP antibody; FAP48 antibody; FAP68 antibody; FK506 binding protein associated protein antibody; FK506-binding protein-associated protein antibody; FKBP associated protein antibody; FKBP-associated protein antibody; FKBP-associated protein, 48-KD antibody; FKBP-associated protein, 68-KD antibody; FKBPAP antibody; GLML antibody; Glmn antibody; GLMN_HUMAN antibody; Glomulin antibody; glomulin, FKBP associated protein antibody; GVM antibody; VMGLOM antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human GLMN

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1. Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels. Essential for normal development of the vasculature. Contributes to the regulation of RPS6KB1 phosphorylation.

Gene References into Functions

Our report contributes to document the possible association between the c.395-1G>C mutation of GLMN gene and glomuvenous malformations. PMID: 24961656
FAP48 adipocyte expression plays a key role in HIV-associated lipodystrophy. PMID: 22678819
These data identify glomulin as a permissivity factor for VACV infection and as a potential therapeutic target for inhibition of vaccinia virus (VACV) infection. PMID: 22280104
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin-1 RING ligase-mediated turnover of Fbw7. PMID: 22405651
A novel GLMN mutation is described in an Italian family with glomuvenous malformations in which some members present with the less commonly observed phenotype of solitary lesions. PMID: 22092580
Describes the characterizations of 14 different mutations in the glomulin gene in patients with glomuvenous malformations. PMID: 11845407
FAP48-FKBP complexes increase IL2 production PMID: 12604780

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Involvement in disease

Glomuvenous malformations (GVMs)

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 14373

OMIM: 138000

KEGG: hsa:11146

STRING: 9606.ENSP00000359385

UniGene: Hs.49105

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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