GMDS Antibody

Datasheet

Code	CSB-PA009569LA01HU
Size	US$166
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Image	IHC image of CSB-PA009569LA01HU diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of Hela cells with CSB-PA009569LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GMDS Polyclonal antibody

Uniprot No.

O60547

Target Names

GMDS

Alternative Names

GDP D mannose dehydratase antibody; GDP mannose 4 6 dehydratase antibody; GDP-D-mannose dehydratase antibody; GDP-mannose 4,6 dehydratase antibody; GMD antibody; Gmds antibody; GMDS_HUMAN antibody; OTTHUMP00000017756 antibody; OTTHUMP00000232770 antibody; SDR3E1 antibody; Short chain dehydrogenase/reductase family 3E member 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human GDP-mannose 4,6 dehydratase protein (243-346AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The GMDS Antibody (Product code: CSB-PA009569LA01HU) is Non-conjugated. For GMDS Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA009569LB01HU	GMDS Antibody, HRP conjugated	ELISA
FITC	CSB-PA009569LC01HU	GMDS Antibody, FITC conjugated
Biotin	CSB-PA009569LD01HU	GMDS Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.

Gene References into Functions

Data indicate three loci associated with primary open-angle glaucoma (POAG) were located upstream of ATP binding cassette transporter 1 (ABCA1), within actin filament associated protein 1 (AFAP1) and within GDP-mannose 46-dehydratase (GMDS). PMID: 25173105
These data demonstrate involvement of GMDS mutation in the progression of colorectal cancer. PMID: 23922970
Fx enzyme and GDP-L-Fuc Tr overexpression in the tumur tissue of colorectal cancer (CRC) patients suggests that GDP-L-Fuc transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC. PMID: 23730929
GMD inhibits tankyrase 1 poly(ADP-ribose) polymerase activity in vitro, dependent on the GMD tankyrase 1 binding motif. In vivo, depletion of GMD led to degradation of tankyrase 1, dependent on the catalytic PARP activity of tankyrase 1. PMID: 22645305
Results indicate that GMDS regulates the formation of secondary complex II from the primary DISC independent of direct fucosylation of death receptors. PMID: 22027835
FX takes part in the cascade of events leading to the extravasation of activated lymphocytes. PMID: 11831876
Deficiency of GMDS leads to escape from natural killer cell-mediated tumor surveillance through modulation of TRAIL signaling. PMID: 19361506

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Protein Families

NAD(P)-dependent epimerase/dehydratase family, GDP-mannose 4,6-dehydratase subfamily

Database Links

HGNC: 4369

OMIM: 602884

KEGG: hsa:2762

STRING: 9606.ENSP00000370194

UniGene: Hs.144496

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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