GMPR2 Antibody

Datasheet

Code	CSB-PA873740LA01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GMPR2 Polyclonal antibody

Uniprot No.

Q9P2T1

Target Names

GMPR2

Alternative Names

GMPR2GMP reductase 2 antibody; GMPR 2 antibody; EC 1.7.1.7 antibody; Guanosine 5'-monophosphate oxidoreductase 2 antibody; Guanosine monophosphate reductase 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human GMP reductase 2 protein (1-366AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The GMPR2 Antibody (Product code: CSB-PA873740LA01HU) is Non-conjugated. For GMPR2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA873740LB01HU	GMPR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA873740LC01HU	GMPR2 Antibody, FITC conjugated
Biotin	CSB-PA873740LD01HU	GMPR2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.

Gene References into Functions

Loss of expression of GMPR2 and PPARalpha is associated with breast cancer basal phenotype; indicating that they may play a role in carcinogenesis. PMID: 23208589
A single crystal structure of human GMPR type 2 with IMP and NADPH fortuitously captures three different states, each of which mimics a distinct step in the catalytic cycle of guanosine monophosphate reductase(GMPR). PMID: 22037469
Data suggest the existence of two distinct types of human GMP reductase molecular species, which can be used to explain the bimodal saturation curve noted with purified human erythrocyte GMP reductase. PMID: 12009299
GMPR2 is a novel human GMP reductase, and overexpression of GMPR2 can promote the monocytic differentiation of HL-60 leukemia cells. PMID: 12669231

Protein Families

IMPDH/GMPR family, GuaC type 1 subfamily

Tissue Specificity

Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.

Database Links

HGNC: 4377

OMIM: 610781

KEGG: hsa:51292

STRING: 9606.ENSP00000392859

UniGene: Hs.368855

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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