GNAT3 Antibody, FITC conjugated

Code CSB-PA009600LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GNAT3 Polyclonal antibody
Uniprot No.
Target Names
GNAT3
Alternative Names
GDCA antibody; Ggust antibody; Gnat 3 antibody; GNAT3 antibody; GNAT3_HUMAN antibody; Gtn antibody; Guanine nucleotide binding protein alpha transducing 3 antibody; Guanine nucleotide binding protein G(t) subunit alpha 3 antibody; Guanine nucleotide-binding protein G(t) subunit alpha-3 antibody; Gustducin alpha 3 antibody; Gustducin alpha 3 chain antibody; Gustducin alpha-3 chain antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Guanine nucleotide-binding protein G(t) subunit alpha-3 protein (2-354AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
Gene References into Functions
  1. (GNAT3, 11 SNPs) gene, located within the 1-LOD support interval region for their association with MS and its related traits. Several SNPs were associated with MS and its related traits. Remarkably. PMID: 22456541
  2. The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY. PMID: 21324568
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20858777
  4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20660057
  5. the alpha-subunit of the taste-specific G protein gustducin is expressed prominently in cells of the human colon PMID: 16728727
  6. Axonemal-associated localization within the midpiece and principal piece of human spermatozoa raises the possibility that this G protein alpha-subunit may process intracellular signals controlling sperm motility. PMID: 17021831

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Subcellular Location
Cytoplasm. Note=Dual distribution pattern; plasmalemmal pattern with apical region localization and cytosolic pattern with localization throughout the cytoplasm.
Protein Families
G-alpha family, G(i/o/t/z) subfamily
Tissue Specificity
Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate and foliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected also in spermatozoa.
Database Links

HGNC: 22800

OMIM: 139395

KEGG: hsa:346562

STRING: 9606.ENSP00000381339

UniGene: Hs.335049

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