GPHN Antibody

1. endosomal pool of PI3P, generated by the class III phosphatidylinositol 3-kinase, is important for the Cb-mediated recruitment of gephyrin and GABAA receptors to developing inhibitory postsynapses and thus the formation of postsynaptic membrane specializations. PMID: 27941024
2. these data reveal that IQSEC3 acts together with gephyrin to regulate inhibitory synapse development. PMID: 27002143
3. CDK5 plays an essential role for the stability of gephyrin-dependent GABAA receptor clusters in hippocampal neurons. PMID: 25093719
4. These results reveal a homeostatic mechanism through which activity regulates the dynamics and function of perisomatic inhibitory synapses, and they identify a CaMKII-dependent phosphorylation site on gephyrin. PMID: 25535349
5. A rationale is provided for the role of the 150-residue linker in the overall structure and conformational dynamics of gephyrin. A high degree of flexibility is revealed in its structure, and both terminal domains can oligomerize in their isolated forms. PMID: 24100323
6. The enhancement of Cb-induced gephyrin clustering by GTP-TC10 does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors PMID: 24297911
7. Nanoscopic imaging based on single-molecule detections characterizes the ultrastructure of inhibitory synapses and counts the number of scaffold proteins and receptor binding sites. PMID: 23889935
8. The changes in protein expression of gephyrin detected in these studies provide a potential mechanism to explain the deficits in GABAergic neurotransmission observed during the epileptogenic period PMID: 23294024
9. Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin. PMID: 22778260
10. There may be a correlation between the distribution density of gephyrin clusters in the submembrane region of ventromedial (Vm) motoneurons and that of axon terminals making inhibitory synapses on Vm motoneurons. PMID: 22290869
11. We propose two models for the domain arrangement in hexameric gephyrin based on the oligomerization of either the E or C domains, with the latter being crucial for the regulation of gephyrin clustering. PMID: 22351777
12. Gephyrin expression is involved in the development of temporal lobe epilepsy in an experimental rat model. PMID: 21404332
13. clustering of GABA(A)R alpha2, alpha3, and GlyRs by gephyrin is mediated by distinct mechanisms at mixed glycinergic/GABAergic synapses. PMID: 21880742
14. a key role of gephyrin in regulating transynaptic signaling at both inhibitory and excitatory synapses. PMID: 21507951
15. Conditioned fear increased the number of cells co-expressing GABA-A receptor alpha-2 subunits and gephyrin in the basolateral amygdala and dentate gyrus of the hippocampus in high anxiety rats. PMID: 20833253
16. Gephyrin is a synaptogenic molecule regulating GABAergic synaptic plasticity, and likely contributes to the therapeutic action of lithium. PMID: 21173228
17. Data are consistent with the postsynaptic gephyrin scaffold acting as a platform for protein phosphatase 1 (PP1), which regulates gephyrin cluster size by dephosphorylation of gephyrin- or cytoskeleton-associated proteins. PMID: 20206270
18. These results indicate that gephyrin is essential not only for maintaining synaptic GABA(A) receptor clusters in the right position but also for regulating both phasic and tonic inhibition. PMID: 19660531
19. Gephyrin, profilin and Mena/VASP colocalize at rat spinal cord synapses, cultured neurons and in gephyrin clusters in transfected cells. Mena/VASP and profilin can contribute to postulated linkage between receptors, gephyrin scaffolds and microfilaments PMID: 12967995
20. These results identify the C5 splice variant of gephyrin as a factor regulating the transmitter-appropriate degree of Glycine receptor accumulation at inhibitory synapses PMID: 14960612
21. The structural basis of dynamic glycine receptor clustering by gphn was studied. PMID: 15201864
22. Results implicate gephyrin in fear acquisition and extinction and suggest that modulation of gephyrin and GABA(A) receptor expression in the basolateral amygdala may play a role in the experience-dependent plasticity underlying these types of learning. PMID: 15647495
23. Data suggest that ena/VASP binding to F-actin allows for gephyrin recruitment to the leading edge of uncapped actin filaments. PMID: 16376568
24. The resolution crystal structure of the Cdc42-collybistin II complex reveals a novel conformation of the switch I region of Cdc42, and biochemical data indicate that gephyrin negatively regulates collybistin activity [collybistin II]. PMID: 16616186
25. The expression of various gephyrin isoforms in rat brain, liver, and spinal cord is reported. PMID: 17001074
26. These findings indicate that the expression of gephyrin and the density of cortical inhibitory synapses are not influenced by endogenous neurosteroids. PMID: 17698049
27. It is concluded that gephyrin plays a critical role for the stability of GABAergic synapses. PMID: 17916433
28. The levels of expression and clustering of gephyrin not only has homotypic effects on GABAergic synaptic contacts, but also has heterotypic effects on glutamatergic synaptic contacts. PMID: 18199120
29. Data suggest that gephyrin alterations due to protein accumulation stress are reduced by the lysosomal modulator Z-Phe-Ala-diazomethylketone.( PMID: 18204977
30. Expression of Gphn was studied in the cochlea. PMID: 18231803
31. Clustering of gephyrin occurs in concert with that of GABA-A receptors, with striking differences in the temporal regulation of gephyrin at dendritic and somatic synapses of Purkinje cells. PMID: 18366064
32. A significant increase in the inhibitory postsynaptic scaffold protein, gephyrin, was observed in the parietal cortex of aged cognitively impaired animals. PMID: 19105974
33. crystal structure of N terminal G domain PMID: 11554796

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KEGG: rno:64845

UniGene: Rn.11032