GPR52 Antibody, HRP conjugated

Code CSB-PA896700LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GPR52 Polyclonal antibody
Uniprot No.
Target Names
GPR52
Alternative Names
GPR52; G-protein coupled receptor 52
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human G-protein coupled receptor 52 protein (225-265AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum. Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation.
Gene References into Functions
  1. Data show that G protein-coupled receptor 52 (Gpr52) modulates huntingtin protein (Htt) levels in the striatal cells in vitro and in vivo. PMID: 25738228
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Expressed in brain, especially in striatum.
Database Links

HGNC: 4508

OMIM: 604106

KEGG: hsa:9293

STRING: 9606.ENSP00000356658

UniGene: Hs.673850

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