GPSM1 Antibody

1. The G-protein Regulatory motif of AGS3 is critical for regulating MUC1/Muc1 expression and cytokine production in the inflammatory microenvironment. PMID: 27270970
2. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and AGS3 in fine-tuning TRPC4 activities. PMID: 26987813
3. Activator of G-protein Signaling 3 is an important regulator of esophageal squamous cell carcinoma proliferation PMID: 25812748
4. Results confirmed that Ric-8A can directly bind to AGS3S but failed to facilitate Galpha(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha(i/o)-GDP complex in a cellular environment. PMID: 25480567
5. High GPSM1 gene methylation is associated with gastric tumor aggressiveness. PMID: 25740824
6. Data identified three new loci for type 2 diabetes with genome-wide significance: MIR129-LEP, GPSM1 and SLC16A13. PMID: 23945395
7. Our data indicate that decreased expression of AGS3 is correlated with reduced levels of p-CREB in the apoptotic model. The negative role of AGS3 in cell apoptosis was further confirmed by knocking down AGS3. PMID: 24307516
8. these results indicate that GRK6 complexes with AGS3-Galphai2 to regulate CXCR2-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane. PMID: 24510965
9. These results provide mechanistic insights into how reversible modulation of Galpha(i3) activity by AGS3 and GIV maintains the delicate equilibrium between promotion and inhibition of autophagy. PMID: 21209316
10. AGS3 receptor coupling to both Galphabetagamma and GPR-Galpha(i) offer additional flexibility for systems to respond and adapt to challenges and orchestrate complex behaviors PMID: 20716524
11. unlike wild-type AGS3, over-expression of an AGS3 mutant lacking this modification fails to enhance macroautophagic activity. These observations imply that AGS3 phosphorylation may participate in the modulation of macroautophagy PMID: 20126274
12. These data present AGS3, G-proteins, and mInsc as candidate proteins involved in regulating cellular stress associated with protein-processing pathologies. PMID: 20065032
13. AGS3 is involved in an early event during the autophagic pathway probably prior to the formation of the autophagosome. PMID: 12642577
14. cortical localization in mitotic cell culture systems and requirement for normal cell cycle progression PMID: 12925752
15. data support a model wherein AGS3 modulates the protein trafficking along the TGN/plasma membrane/endosome loop PMID: 17991770
16. The GPR motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase activator as initially suggested. PMID: 10969064

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HGNC: 17858

OMIM: 609491

KEGG: hsa:26086

STRING: 9606.ENSP00000392828

UniGene: Hs.239370