GSC Antibody

Code CSB-PA119398
Size US$100
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  • Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200
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Product Details

Uniprot No.
Target Names
GSC
Alternative Names
Goosecoid antibody; goosecoid homeobox antibody; GSC antibody; GSC_HUMAN antibody; Homeobox protein goosecoid antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide from Human protein at AA range: 207-256
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Purification Method
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form
Liquid
Tested Applications
IHC,ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:50-300
ELISA 1:10000-20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.
Gene References into Functions
  1. Performed mutational analysis of TCOF1, GSC, and HOXA2 to determine the mutational features of the 3 genes in Chinese patients with Treacher Collins syndrome. PMID: 27526242
  2. We find that DIGIT is divergent to Goosecoid (GSC) and expressed during endoderm differentiation. Deletion of the SMAD3-occupied enhancer proximal to DIGIT inhibits DIGIT and GSC expression and definitive endoderm differentiation. PMID: 27705785
  3. 5 genomic variants in GSC, HOXA2 and PRKRA were identified through mutational analysis in Chinese patients with microtia. PMID: 28109504
  4. GSC is also a prognostic factor for poor survival and metastasis of HCC, which suggests its potential as a therapeutic target for metastatic HCC. PMID: 25343336
  5. Results suggest that GSC is the most potential biomarker of drug response and poor prognosis in ovarian serous carcinomas. PMID: 24858567
  6. EtOH exposure increased the expression of an organizer specific gene, goosecoid, in human embryonic carcinoma cells. PMID: 23378141
  7. SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid. PMID: 24290375
  8. GSC represses EVX1 expression and is required for development of anterior primitive-streak-like cell progeny in response to activin. PMID: 22178155
  9. The goosecoid gene mutation in exon 3 may be involved in the malformation events (microtia) in this family. PMID: 20195123
  10. Goosecoid promotes tumor cell malignancy and suggest that other conserved organizer genes may function similarly in human cancer PMID: 17142318
  11. GSC protein might contribute to the observed phenotype. PMID: 18074379

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Involvement in disease
Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS)
Subcellular Location
Nucleus.
Protein Families
Paired homeobox family, Bicoid subfamily
Database Links

HGNC: 4612

OMIM: 138890

KEGG: hsa:145258

STRING: 9606.ENSP00000238558

UniGene: Hs.440438

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