HACL1 Antibody

Datasheet

Code	CSB-PA546627
Size	US$166
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Image	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human testis tissue, mouse liver tissue, Hela cells, 293T cells, Primary antibody: CSB-PA546627(HACL1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
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Product Details
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Target Background

Product Details

Uniprot No.

Q9UJ83

Target Names

HACL1

Alternative Names

1600020H07Rik antibody; 2 HPCL antibody; 2 hydroxyacyl CoA lyase 1 antibody; 2 hydroxyphytanoyl CoA lyase antibody; 2-HPCL antibody; 2-hydroxyacyl-CoA lyase 1 antibody; 2-hydroxyphytanoyl-CoA lyase antibody; FLJ55041 antibody; Hacl1 antibody; HACL1_HUMAN antibody; HPCL antibody; HPCL2 antibody; HSPC279 antibody; PHYH2 antibody; Phytanoyl CoA 2 hydroxylase 2 antibody; Phytanoyl CoA hydroxylase 2 antibody; Phytanoyl-CoA 2-hydroxylase 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human HACL1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids. Plays a significant role in the biosynthesis of heptadecanal in the liver.

Gene References into Functions

Data show that a easy assay for 2-hydroxyacyl-CoA lyase (HACL1) and sphingosine-1-phosphate lyase (SGPL1) activities was developed. PMID: 24323699
Transport of thiamine pyrophosphate into peroxisomes is dependent on HACL1 import, without requirement of a specific solute transporter. PMID: 21708296
2-hydroxyphytanoyl-CoA lyase has a role in the breakdown of long chain 2-hydroxyfatty acids PMID: 15644336
peroxisomal thiamine-pyrophosphate depending enzyme required for the degradation of phytanic acid, catalyzing the cleavage of 2-hydroxyphytanoyl-CoA lyase into formyl-CoA and pristanal PMID: 10468558

Subcellular Location

Peroxisome.

Protein Families

TPP enzyme family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 17856

OMIM: 604300

KEGG: hsa:26061

STRING: 9606.ENSP00000323811

UniGene: Hs.63290

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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