HCLS1 Antibody

Datasheet

Code	CSB-PA009155
Size	US$119
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P14317

Target Names

HCLS1

Alternative Names

Cortactin like antibody; CTTNL antibody; HCLS 1 antibody; Hcls1 antibody; HCLS1_HUMAN antibody; Hematopoietic cell specific Lyn substrate 1 antibody; Hematopoietic cell-specific LYN substrate 1 antibody; Hematopoietic lineage cell-specific protein antibody; HS 1 antibody; HS1 antibody; LckBP1 antibody; OTTHUMP00000215180 antibody; OTTHUMP00000215182 antibody; p75 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from Human Lck BP-1 around the non-phosphorylation site of Y397.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.

Gene References into Functions

these studies indicate HS1 plays an important role in ROR1-dependent Wnt5a-enhanced chemokine-directed leukemia-cell migration. PMID: 28465529
SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells. PMID: 25359136
Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. PMID: 23017497
interaction of HCLS1 with LEF-1 is essential for G-CSF-triggered myeloid differentiation; data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo PMID: 23001182
HS1 overexpressed in leukemic as compared to normal B lymphocytes. PMID: 22768161
a novel role for HS1 and its phosphorylation during neutrophil directed migration. PMID: 22679023
High HS1 expression predicts poor survival of chronic lymphocytic leukemia patients. PMID: 22333038
SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs. PMID: 21287358
HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in chronic lymphocytic leukemia. PMID: 20530793
substrate for caspase cleavage during apoptosis PMID: 11689006
TBB induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. PMID: 11988074
found in cell types other than hematopoietic cells PMID: 15754022
HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets PMID: 15795233
The HS1 coiled-coil region acts synergistically with the repeat domain in the modulation of the Arp2/3 complex-mediated actin polymerization. PMID: 16157603
HS1 may play a role in cytoskeleon organization in B-cells and leukemic B-cells PMID: 17508001

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Subcellular Location

Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.

Tissue Specificity

Expressed only in tissues and cells of hematopoietic origin.

Database Links

HGNC: 4844

OMIM: 601306

KEGG: hsa:3059

STRING: 9606.ENSP00000320176

UniGene: Hs.14601

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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