HERC5 Antibody

1. Low HERC5 expression is associated with HIV infections. PMID: 29669830
2. A synonymous mutation at rs6857425 (T-C) was present in the same region among all study groups (T-C), irrespective of their HIV status. PMID: 28737979
3. Results show that HERC5 mediates covalent ISG15 conjugation to parkin in mammalian cells and that ISG15 is conjugated to the Lys349 and Lys369 residues of parkin. PMID: 27534820
4. HERC5 plays a crucial role in HCC immune evasion and has clinical relevance as a reproducible prognostic marker for risk of tumor recurrence and survival in patients. PMID: 26653219
5. The inhibitory effect of ISG15 on HCV RNA replication does not require its conjugation to substrates by HERC5. PMID: 26361997
6. vIRF1 association with HERC5 altered ISG15 modification of cellular proteins, and knockdown of ISG15 augmented reactivation of KSHV from latency. PMID: 26355087
7. The study reports on the NMR solution structure of a G-quadruplex formed by the CEB1 DNA G-rich fragment d(AGGGGGGAGGGAGGGTGG), harboring several G-tracts including one with six continuous guanines. PMID: 24742225
8. Results show that HERC5 gene may be involved in regulating the spread of non-small cell lung cancer tumors where the methylation of its promoter is correlated with number increase of disseminated tumor cells and metastases as well as survival decreased. PMID: 25353388
9. Authors identified a second distinct mechanism by which HERC5 inhibits HIV-1 replication and demonstrate that HERC5 is evolving under strong positive selection. PMID: 24693865
10. Data indicate that income was inversely related to smoking behavior, and paternally derived CEB1 mutations were dose dependently increased when the father smoked in the 6 mo before pregnancy, 0.21 vs. 0.05 in smoking and nonsmoking fathers, respectively. PMID: 23538710
11. The E3 ligase activity of HERC5 was required for blocking HIV-1 Gag particle production and correlated with the post-translational modification of Gag with ISG15. PMID: 22093708
12. This study characterizes HERC5 as a positive regulator of innate antiviral responses, and show that it sustains IRF3 activation via a novel posttranslational modification, ISG15-ylation. PMID: 20308324
13. Data show that HERC5, a functionally active HECT ubiquitin ligase, exhibits a tightly controlled cytosolic level under inflammatory conditions in endothelial cells. PMID: 15331633
14. HERC5/Ceb1 is involved in the conjugation of ISG15 to cellular proteins. PMID: 16815975
15. these results suggest that Herc5 functions as a general E3 ligase for protein ISGylation. PMID: 16884686
16. Overexpression of cyclin E is associated with neuroendocrine lung tumors PMID: 17471231

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HGNC: 24368

OMIM: 608242

KEGG: hsa:51191

STRING: 9606.ENSP00000264350

UniGene: Hs.26663