JPT1 Antibody, FITC conjugated

1. Downregulation of MYC abrogated the effect of HN1 overexpression in breast cancer cell lines. Taken together, these data reveal that HN1 promotes the progression of breast cancer by upregulating MYC expression, and might be a therapeutic target for breast cancer. PMID: 28490334
2. Data report that HN1 is an essential factor for beta-catenin turnover and signaling, augments cell growth and migration in prostate cancer cells. PMID: 25169422
3. miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3' UTR of HN1. PMID: 25450365
4. HN1 maintains a balance between the androgen-regulated nuclear translocation of androgen receptor and steady-state Akt phosphorylation, predominantly in the absence of androgens. PMID: 22155408
5. EGF and kinase inhibitors increase HN1 expression, and Silencing of HN1 results in cell cycle alterations in prostate cells. PMID: 21323578
6. These data suggest a role for Hn1 in the biology of malignant brain tumors. PMID: 19145478

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HGNC: 14569

KEGG: hsa:51155

STRING: 9606.ENSP00000348316

UniGene: Hs.532803