HNRNPLL Antibody, FITC conjugated

Code CSB-PA010630LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HNRNPLL Polyclonal antibody
Uniprot No.
Target Names
HNRNPLL
Alternative Names
BLOCK24 antibody; Heterogeneous nuclear ribonucleoprotein L like antibody; Heterogeneous nuclear ribonucleoprotein L-like antibody; HNRLL_HUMAN antibody; hnRNPLL antibody; HNRPLL antibody; SRRF antibody; Stromal RNA regulating factor antibody; Stromal RNA-regulating factor antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Heterogeneous nuclear ribonucleoprotein L-like protein (1-72AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
Gene References into Functions
  1. Loss-of-function mutation of hnRNPLL disrupts peripheral T cell accumulation even in the absence of CD45 protein, indicating that hnRNPLL acts through an independent mechanism to promote peripheral T cell longevity. PMID: 20505149
  2. Participation of SRRF (Stromal RNA Regulating Factor) isoforms in post-transcriptional events in bone marrow stromal cells; an important role in regulation of the RNA expression that directs the bone marrow stromal cells differentiation pathway PMID: 15256261
  3. identification of heterogeneous ribonucleoprotein L-like (hnRNPLL) as a critical inducible regulator of CD45 alternative splicing PMID: 18669861
  4. These data establish that hnRNP LL plays a critical and unique role in the signal-induced regulation of CD45 and demonstrate the utility of cell-based screens for the identification of novel splicing regulatory factors. PMID: 18719244
Tissue Specificity
Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.
Database Links

HGNC: 25127

OMIM: 611208

KEGG: hsa:92906

STRING: 9606.ENSP00000387088

UniGene: Hs.445497

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