HOPX Antibody

1. Data suggest that HOP homeobox HOPX (HOPX) acts as a tumour suppressor via the epigenetic regulation of snail family transcription factors (SNAIL) transcription and a prognostic biomarker for nasopharyngeal carcinoma (NPC) metastasis and therapeutic target for NPC treatment. PMID: 28146149
2. HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis PMID: 27934959
3. The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop) is a useful prototype to study the fundamental molecular details about the Hop-Hsp90 interaction. Observed are conformational changes of the peptide and the protein receptor induced by binding. The binding free energy is 8.4 kcal/mol. PMID: 28723223
4. HOPX is functionally regulated by SCL in hematoendothelial differentiation of mesoderm progenitor cells. PMID: 28813672
5. HOPX is a distinctive homeobox gene with characteristic clinical and biological implications and its expression is a powerful predictor of prognosis in AML patients. PMID: 28341738
6. HOPX has a role in the pathogenesis of skin cancers and skin diseases. PMID: 27017330
7. these data indicate that the disruption of the PrP(C)-HOP complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC). PMID: 27112151
8. HOPX promoter methylation is not only frequent and cancer-specific but also associated with aggressive phenotype in breast cancer. PMID: 27756570
9. Computational results identified HOPX gene as a new potential driver for ovarian carcinogenesis. PMID: 27287041
10. The results suggest that HOPX may contribute to pathogenesis or manifestation of hypertrophic cardiomyopathy as a modifier gene. PMID: 25036325
11. Data show that binding of heat shock proteins Hsp70 and Hsp90 requires prior binding of Hop protein to Hsp90. PMID: 26286954
12. HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer. PMID: 25345926
13. GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype. PMID: 23707782
14. HOPX-beta promoter methylation is a frequent and cancer-specific event in CRC progression. PMID: 22904674
15. Knockdown of Hop caused a decrease in the level of RhoC GTPase, and significantly inhibited pseudopodia formation in Hs578T cells. Our data suggest that Hop regulates directional cell migration by multiple unknown mechanisms. PMID: 23036489
16. HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure. PMID: 21382376
17. results identify distinct functions for the Hop cochaperone, revealing an asymmetric mechanism for Hsp90 regulation and client loading PMID: 21700222
18. HOP is a novel modulator of late terminal differentiation in keratinocytes PMID: 21256618
19. Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas-induced apoptosis. PMID: 21061432
20. HOPX-beta promoter methylation is a frequent and cancer-specific event in gastric cancer PMID: 20228841
21. HOPX is modulated by cell differentiation in human keratinocytes and this might contribute to homeostasis of keratinocytes by controlling differentiation-dependent genes. PMID: 20226564
22. Loss of NECC1 expression is involved in malignant conversion of placental trophoblasts. PMID: 12573257
23. Gene mapping locates LAGY on chromosome 4q11-13.1. In 72 primary lung tumors, this gene was significantly down-regulated compared to 9 normal lung tissue samples. PMID: 12759545
24. One role of Hop is to modify the expression of cardiac-specific genes and thereby finely regulate heart development. PMID: 14522464
25. Decrease in homeodomain-only protein is associated with hypopharyngeal carcinoma PMID: 15213722
26. SMAP31 expression is elevated in 4 of 6 papillary thyroid tumor samples compared to 4 normal thyroid controls. PMID: 15307938
27. loss of NECC1 expression is involved in malignant conversion of placental trophoblasts PMID: 15457851
28. Our results demonstrate that the homeodomain fold has been co-opted during evolution for functions other than sequence-specific DNA binding and suggest that HOP functions as an adaptor protein to mediate transcriptional repression. PMID: 16939210
29. The data indicate that signaling induced by hop/STI-1 depends on endocytosis PMID: 17498662
30. Gradual induction of HOP/NECC1 in response to differentiation stimuli may result in the decision to differentiate into a particular type of trophoblastic cell lineage and result in non-lethal defects PMID: 17576768
31. HOP is a putative tumor suppressor gene that harbors tumor inhibitory activity. PMID: 18234960
32. HOP may work as a tumor suppressor in a subset of glioblastomas; HOP function thus appears to be critical in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease PMID: 18507846
33. transcriptional silencing of HOPX results from hypermethylation of the HOPpromoter, which leads to human uterine endometrial cancers (HEC) development. PMID: 19173292

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HGNC: 24961

OMIM: 607275

KEGG: hsa:84525

STRING: 9606.ENSP00000450527

UniGene: Hs.619396