HOXA4 Antibody, Biotin conjugated

1. HOXA4/HOXB3 gene expression-based risk score may be useful for prognostic risk stratification and warrants prospective validation in HGSOC patients. PMID: 29402501
2. Overexpression of HOXA4 and HOXA9 contributes to self-renewal and overpopulation of stem cells in colorectal cancers. PMID: 28464221
3. HOXA4 increases short-term repopulation to higher levels than HOXB4, which may involve Notch signaling to induce self-renewal of primitive hematopoietic cells PMID: 26166023
4. The NK AML patients with NPM1 mutations exhibited elevated HOXA4 methylation and expression levels of HOXA5 and MEIS1 compared with the NPM1 wildtype patients. PMID: 25585874
5. promoter hypermethylation of HOXA4 gene could be an epigenetic mechanism mediating IM resistance in CML patients. PMID: 23484077
6. HOXA4 showed nuclear & perinuclear staining in endothelial & smooth muscle cells in aorta. Spatial variation in expression in human aortas persisted into adulthood. Downregulation of HOXA4 expression was associated with abdominal aortic aneurysm. PMID: 21627813
7. Studies suggest that HOXA4, HOXA5 and HOXB4 provide the spatial information needed to restrict the response to signals from the notochord, and not up regulated in pancreatic cancer. PMID: 21546695
8. Results confirm that HOXA4 inhibits cell motility, show that it suppresses cell spreading and filopodia formation while enhancing cell-cell adhesion, and suggest a role for beta1 integrin in mediating these changes. PMID: 19723874
9. upregulated significantly in acute myeloid leukemia patients with a white blood cell count higher than 30 x 10(9)/L cells. PMID: 12031912
10. aberrant DNA methylation may have a major role in the control of HOXA4 gene expression in chronic lymphocytic leukemia PMID: 16688227
11. analysis of the role of deregulated PcG genes in acute myeloid leukemia, and the downstream PcG targets HOXA4, HOXA9 and MEIS1 PMID: 18410541
12. combination of low HOXA4 and low MEIS1 gene expression is a favourable predictor for outcome in all AML patients and that the expression levels are governed by the methylation state of these genes. PMID: 19563517

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HGNC: 5105

OMIM: 142953

KEGG: hsa:3201

STRING: 9606.ENSP00000353151

UniGene: Hs.533357