HSCB Antibody, HRP conjugated

Code CSB-PA816893LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HSCB Polyclonal antibody
Uniprot No.
Target Names
HSCB
Alternative Names
AI325508 antibody; AW049829 antibody; dJ366L4.2 antibody; DnaJ (Hsp40) homolog, subfamily C member 20 antibody; DnaJ homolog subfamily C member 20 antibody; DNAJC20 antibody; Hsc20 antibody; HSC20_HUMAN antibody; hscB antibody; HscB iron sulfur cluster co chaperone homolog antibody; Iron sulfur cluster co chaperone protein HscB mitochondrial antibody; Iron-sulfur cluster co-chaperone protein HscB antibody; J type co chaperone HSC20 antibody; JAC1 antibody; mitochondrial antibody; RGD1311005 antibody; RP3-366L4.2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Iron-sulfur cluster co-chaperone protein HscB, mitochondrial protein (30-235AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT.
Gene References into Functions
  1. Nfu is shown to bind to both chaperone proteins with binding affinities similar to those observed for IscU binding to the homologous HSPA9 and Hsc20, while Nfu can also stimulate the ATPase activity of HSPA9 PMID: 29211945
  2. The delivery of assembled Fe-S clusters to recipient proteins is a crucial step in the biogenesis of Fe-S proteins; review focuses on recent insights into the molecular mechanism of amino acid motif recognition and discrimination by the co-chaperone HSC20 and finds co-chaperone HSC20 binds to LYR motifs present in Fe-S recipient proteins or their binding partners. [Review] PMID: 27714045
  3. the crucial role of HSC20 in the assembly of the mitochondrial respiratory chain, is reported. PMID: 28380382
  4. NFS1 binds preferentially to the D-state of ISCU while mtHSP70 binds preferentially to the D-state of ISCU and HSC20 binds preferentially to the S-state of ISCU. PMID: 23940031
  5. A cysteine-rich N-terminal domain, which clearly distinguishes hHSC20 from the specialized DnaJ type III proteins of fungi and most bacteria, was found to be important for the integrity and function of the human co-chaperone. PMID: 20668094
  6. structural analysis of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain PMID: 18713742

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Subcellular Location
[Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm.; [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion.
Protein Families
HscB family
Tissue Specificity
Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.
Database Links

HGNC: 28913

OMIM: 608142

KEGG: hsa:150274

STRING: 9606.ENSP00000216027

UniGene: Hs.632780

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