HTR3E Antibody,Biotin conjugated

Code CSB-PA010894LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HTR3E Polyclonal antibody
Uniprot No.
Target Names
HTR3E
Alternative Names
HTR3E; 5-hydroxytryptamine receptor 3E; 5-HT3-E; 5-HT3E; Serotonin receptor 3E
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 5-hydroxytryptamine receptor 3E protein (26-248AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Antigen Affinity purified & Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Gene References into Functions
  1. the HTR3E remained significant after correction for the number of variants investigated. PMID: 23928294
  2. Data show that 5-HT3C, 5-HT3D, and 5-HT3E subunits are coexpressed with 5-HT3A in cell bodies of myenteric neurons, and that 5-HT3A and 5-HT3D were expressed in submucosal plexus of the human large intestine. PMID: 21192076
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20538960
  4. Six functional and coding variants of the subunit genes HTR3A, HTR3B as well as the novel HTR3C, HTR3D, and HTR3E subunits in the response to haloperidol or risperidone, were assessed. PMID: 19794330
  5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20602613
  6. This study provides additional evidence for a role of the serotonergic system and the 5-HT3 receptor in schizophrenia PMID: 20356718
  7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20356718
  8. Data show that 5-HT3 receptors locat in the nucleus tractus silitarius contribute to stress-induced suppression of the baroreflex. PMID: 18573276
  9. MicroRNA-510 target site of the 3'UTR of HTR3A and HTR3E are associated with the irritable bowel syndrome with diarrhea. PMID: 18614545
  10. The binding site for miR-510 is solely located in the 3' UTR of the HTR3E gene. No predicted binding site for miR-510 exists in the 3' UTR of HTR3A. PMID: 18614545
  11. Observational study of gene-disease association. (HuGE Navigator) PMID: 20021265

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Protein Families
Ligand-gated ion channel (TC 1.A.9) family, 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily, HTR3E sub-subfamily
Tissue Specificity
Expressed in adult colon and intestine.
Database Links

HGNC: 24005

OMIM: 610123

KEGG: hsa:285242

STRING: 9606.ENSP00000335511

UniGene: Hs.449179

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