Function
Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity.
Gene References into Functions
- Our data provide evidence that heterozygous variants in ICK caused juvenile myoclonic epilepsy in 7% of the patients included in our analysis. Variant ICK affects cell processes that help explain microdysgenesis and polyspike networks observed on EEG in juvenile myoclonic epilepsy. PMID: 29539279
- These data identify ICK as an short rib polydactyly syndromes (SRPS)-associated gene and reveal that abnormalities in signalling pathways contribute to defective skeletogenesis PMID: 27466187
- findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress. PMID: 25184386
- the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
- In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. PMID: 23743448
- High ICK expression is associated with prostate cancer. PMID: 22761715
- an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908. PMID: 22356909
- ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity PMID: 19185282
- Findings demonstrate an important role for ICK in proliferation and differentiation of intestinal epithelial cells. PMID: 19696144
- ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. PMID: 20459822
- PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe, an essential regulator of proliferation and apoptosis during mammalian development. PMID: 16954377
- ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1, c-Myc and p21Cip1. PMID: 19696144
- ICK is the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs. PMID: 15988018
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Involvement in disease
Endocrine-cerebroosteodysplasia (ECO)
Subcellular Location
Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.; [Isoform 2]: Cytoplasm.
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Tissue Specificity
Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
