IFRD1 Antibody

1. Results from a study on gene expression variability markers in early-stage human embryos shows that IFRD1 is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
2. High IFRD1 colon cancer expression was significantly associated with decreased 5-year patient survival. PMID: 29094309
3. this study shows that IFRD1 gene may be associated with pathogenesis of asthma PMID: 27842724
4. rs7817 polymorphism associated with nasal polyposis in cystic fibrosis patients PMID: 26397160
5. study reveals an EGFR-IFRD1-mediated viral immune evasion mechanism, which can also be exploited by cancer cells PMID: 26055519
6. rs5009270 may contribute to hip OA susceptibility by altering proximal femur shape. PMID: 25939412
7. PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta. PMID: 25308091
8. Studied the association between IFRD1 polymorphisms and gastric cancer in a Chinese population. PMID: 25073439
9. IFRD1 expression is systemically up-regulated in CF neutrophils, is linked to the production of ROS, and is modulated by chemokines in CF airway fluids, depending on the IFRD1 genotype. PMID: 23043087
10. This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models. PMID: 21723850
11. IFRD1 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
12. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in rat as nerve growth factor-inducible immediate early gene (named PC4). PMID: 2467301
13. IFRD1 is an inducer of skeletal muscle regeneration and of satellite cell amplification, by regulating MyoD and NF-kB. PMID: 21127072
14. Identification of PC4/IFRD1 as a coactivator of MyoD, a key master gene of muscle development. PMID: 15743821
15. In the absence of PC4/IFRD1 skeletal muscle differentiation is defective. PMID: 7756174
16. IFRD1 mRNA decay stress-sensitive regulation is mediated by an upstream open reading frame PMID: 20080976
17. TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes PMID: 16204248
18. identification of IFRD1 as a modifier of cystic fibrosis lung disease severity PMID: 19242412
19. Sequence conservation, animal models, and protein structure evaluation support the involvement of IFRD1 in SMNA PMID: 19409521
20. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7). PMID: 2797820
21. Identification of the IFRD gene family, comprising the two genes PC4 / Tis7 / IFRD1 and SKMc15 / IFRD2, and in situ-hybridization analysis of their expression during developments PMID: 9722946
22. PC4/IFRD1 is able to potentiate the transcription of many genes and to inhibit the transcription of few others, thus acting as regulator of transcription, possibly involved in tissue regeneration PMID: 12691737
23. Functional ablation of PC4/IFRD1 in myoblast cells by sense and antisense strategies as well as by microinjection of PC4/IFRD1 antibodies, inhibits differentiation. PMID: 7756174
24. PC4/IFRD1, known to be required for muscle differentiation, coactivates MyoD by relieving the HDAC4-mediated inhibition of MEF2C, as a result of its ability to dose-dependently displace HDAC4 from MEF2C. PMID: 15743821
25. This reference (Tirone and Shooter 1989) shows the cloning and the sequence of the original IFRD1 homolog, isolated in rat as NGF-inducible immediate early gene (named PC4). PMID: 2467301

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HGNC: 5456

OMIM: 603502

KEGG: hsa:3475

STRING: 9606.ENSP00000005558

UniGene: Hs.744747