INCA1 Antibody

Code CSB-PA605764LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA605764LA01HU at dilution of 1:100
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) INCA1 Polyclonal antibody
Uniprot No.
Target Names
INCA1
Alternative Names
HSD45 antibody; Inca1 antibody; INCA1_HUMAN antibody; Inhibitor of CDK cyclin A1 interacting protein 1 antibody; Inhibitor of CDK interacting with cyclin A1 antibody; MGC148150 antibody; MGC148151 antibody; Protein INCA1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein INCA1 protein (1-236AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The INCA1 Antibody (Product code: CSB-PA605764LA01HU) is Non-conjugated. For INCA1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA605764LB01HU INCA1 Antibody, HRP conjugated ELISA
FITC CSB-PA605764LC01HU INCA1 Antibody, FITC conjugated
Biotin CSB-PA605764LD01HU INCA1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth.
Gene References into Functions
  1. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling PMID: 21540187
  2. Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1. PMID: 21750715
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
INCA family
Tissue Specificity
Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors. Down-regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells.
Database Links

HGNC: 32224

OMIM: 617374

KEGG: hsa:388324

STRING: 9606.ENSP00000380041

UniGene: Hs.658926

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