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Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
Gene References into Functions
results reveal the molecular mechanism of H3K4me3 selection by the ING3PHD and suggest that this interaction is important for mediating ING3 tumor suppressive activities. PMID: 27281824
High ING3 expression is associated with prostate cancer. PMID: 26803516
ING3 levels may serve as a surrogate for growth rate, and suggest possible roles for ING3 in growth and self renewal and related diseases such as cancer. PMID: 25819753
Downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. PMID: 24927342
that ING3 may be an important marker for human hepatocellular carcinoma progression and prognosis, as well as a potential therapeutic target. PMID: 22550337
Data show that ING3 is degraded by the ubiquitin-proteasome pathway through the SCF(Skp2) complex. PMID: 19935701
we have isolated a novel ING family gene, p47ING3, which modulates p53-mediated transcription, cell cycle control, and apoptosis. The p47ING3 gene is located at chromosome 7q31.3 and consists of 12 exons that encode 418 amino acids PMID: 12545155
ING3 may be an important marker for human melanoma progression and prognosis as well as a potential therapeutic target. PMID: 17634537
ING3 would function as a potential tumor suppressor molecule and that low levels of ING3 may indicate an aggressive nature of head and neck cancer. PMID: 18081876
Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. PMID: 12080476
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Involvement in disease
Squamous cell carcinoma of the head and neck (HNSCC)
Subcellular Location
Nucleus.
Protein Families
ING family
Tissue Specificity
Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.