INPP4A Antibody

Datasheet

Code	CSB-PA853479ESR1HU
Size	US$166
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Image	Western blot All lanes: INPP4A antibody at 8.79 μg/ml + Mouse brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 110, 106, 108 kDa Observed band size: 110, 48 kDa Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA853479ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) INPP4A Polyclonal antibody

Uniprot No.

Q96PE3

Target Names

INPP4A

Alternative Names

107kDa antibody; 4-bisphosphate 4-phosphatase antibody; 9630012D15 antibody; D130048C09Rik antibody; Inositol polyphosphate 4 phosphatase type I 107kDa antibody; Inositol polyphosphate 4 phosphatase type I antibody; Inositol polyphosphate 4-phosphatase type I antibody; INP4A_HUMAN antibody; INPP4 antibody; Inpp4a antibody; OTTHUMP00000203138 antibody; OTTHUMP00000203139 antibody; OTTHUMP00000203141 antibody; OTTHUMP00000225217 antibody; R74740 antibody; TVAS1 antibody; Type I inositol 3 4 bisphosphate 4 phosphatase antibody; Type I inositol 3,4 bisphosphate 4 phosphatase antibody; Type I inositol-3 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Type I inositol 3,4-bisphosphate 4-phosphatase protein (1-250AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current.; Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.

Gene References into Functions

Our findings indicate that upregulation of miR-935 may promote pancreatic cancer cell proliferation and migration and inhibit cell apoptosis by targeting INPP4A. PMID: 27733216
INPP4A could possibly serve as a candidate gene for alterations associated with asbestos exposure. PMID: 26463840
Data adds a new etiology to the spectrum of hindbrain malformations in human, and when presented with myoclonic epilepsy may lead to the clinical suspicion of INPP4A defect. PMID: 25338135
INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death PMID: 20463662
in quiescent cells, the 4-phosphatase colocalized with early and recycling endosomes PMID: 15716355
The +110832A/G (Thr/Ala) variant of INPP4A was significantly associated with asthma in an Indian population. PMID: 18187694

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Subcellular Location

Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus. Cytoplasm. Cell junction, synapse, postsynaptic density.

Protein Families

Inositol 3,4-bisphosphate 4-phosphatase family

Tissue Specificity

Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.

Database Links

HGNC: 6074

OMIM: 600916

KEGG: hsa:3631

STRING: 9606.ENSP00000074304

UniGene: Hs.469386

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Phosphatidylinositol signaling system

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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