ISX Antibody

Code CSB-PA011854LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA011854LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA011854LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ISX Polyclonal antibody
Uniprot No.
Target Names
ISX
Alternative Names
DKFZp781N2395 antibody; Intestine-specific homeobox antibody; Isx antibody; ISX_HUMAN antibody; MGC138417 antibody; OTTHUMP00000028558 antibody; Pancreas intestine homeodomain transcription factor antibody; Pix 1 antibody; RAX like homeobox antibody; RAX-like homeobox antibody; RAXLX antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Intestine-specific homeobox protein (1-245AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ISX Antibody (Product code: CSB-PA011854LA01HU) is Non-conjugated. For ISX Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA011854LB01HU ISX Antibody, HRP conjugated ELISA
FITC CSB-PA011854LC01HU ISX Antibody, FITC conjugated
Biotin CSB-PA011854LD01HU ISX Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.
Gene References into Functions
  1. our results indicate that E2F1 is an important downstream gene of ISX in hepatoma progression. PMID: 27175585
  2. Results show that ISX expression mediated AHR-induced tumorigenesis in hepatocellular carcinoma. PMID: 28398627
  3. Overall, our results identified a feed-forward mechanism of immune suppression in hepatocellular carcinoma organized by ISX, which involves kynurenine-AHR signaling and PD-L1, offering insights into immune escape by hepatocellular carcinoma PMID: 28625979
  4. ISX expression induced by H. pylori infection may lead to intestinal metaplasia and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis. PMID: 26872890
  5. Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX PMID: 23393141
  6. our results highlight ISX as an important regulator in hepatoma progression with significant potential as a prognostic and therapeutic target in HCCs. PMID: 23221382

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Subcellular Location
Nucleus.
Database Links

HGNC: 28084

OMIM: 612019

KEGG: hsa:91464

STRING: 9606.ENSP00000311492

UniGene: Hs.567637

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