KANK1 Antibody, FITC conjugated

1. Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1. PMID: 29158259
2. Low KANK1 expression is associated with lung cancer progression. PMID: 29956815
3. KANK1 inhibits Malignant peripheral nerve sheath tumors cell growth though CXXC5 mediated apoptosis. PMID: 28067315
4. Upregulating the Kank1 gene can inhibit the progress of gastric cancer. PMID: 28731169
5. Here, the authors show that cortical microtubule stabilization sites containing CLASPs, KIF21A, LL5beta and liprins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the major adhesion component, talin. Structural studies showed that the conserved KN domain in KANK1 binds to the talin rod domain R7. PMID: 27410476
6. liprin beta-1 is associated with expression of kank 1 and 2 proteins in melanoma PMID: 26739330
7. primary results revealed new function of Kank1 for nasopharyngeal cancer PMID: 25973051
8. identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome. PMID: 25961457
9. Thus, the human brain glioma apoptosis induced by upregulation of the Kank1 gene is closely relevant to the mitochondrial pathway. PMID: 24399197
10. Our case suggests that KANK1 may be subject to random monoallelic expression as a possible mode of inheritance. PMID: 23454270
11. ANKRD15 encodes the kidney ankyrin repeat-containing protein. PMID: 22876580
12. KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia. PMID: 20164854
13. Kank is localized to 9p24 and plays a role in cell growth PMID: 12133830
14. Human Kank gene has several alternative first exons. PMID: 15823577
15. Kank can bind to beta-catenin and regulate the subcellular distribution of beta-catenin. PMID: 16968744
16. Data suggest that Kank negatively regulates the formation of actin stress fibers and cell migration through the inhibition of RhoA activity, which is controlled by binding of Kank to 14-3-3 in PI3K-Akt signaling. PMID: 18458160
17. These results suggest that KIF21A regulates the distribution of Kank1 and that KIF21A mutations associated with congenital fibrosis of the extraocular muscles type 1 enhanced the accumulation of Kank1 in the membrane fraction. PMID: 19559006

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HGNC: 19309

OMIM: 607704

KEGG: hsa:23189

STRING: 9606.ENSP00000371734

UniGene: Hs.306764