KANK2 Antibody, HRP conjugated

Code CSB-PA720638LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KANK2 Polyclonal antibody
Uniprot No.
Target Names
KANK2
Alternative Names
KANK2 antibody; ANKRD25 antibody; KIAA1518 antibody; MXRA3 antibody; SIP antibody; KN motif and ankyrin repeat domain-containing protein 2 antibody; Ankyrin repeat domain-containing protein 25 antibody; Matrix-remodeling-associated protein 3 antibody; SRC-1-interacting protein antibody; SIP antibody; SRC-interacting protein antibody; SRC1-interacting protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human KN motif and ankyrin repeat domain-containing protein 2 protein (410-585AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation.
Gene References into Functions
  1. Using whole-exome sequencing, authors identified a homozygous missense c.2009C>T mutation in KANK2 PMID: 24671081
  2. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. PMID: 17476305
Involvement in disease
Palmoplantar keratoderma and woolly hair (PPKWH)
Subcellular Location
Cytoplasm. Mitochondrion.
Tissue Specificity
Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).
Database Links

HGNC: 29300

OMIM: 614610

KEGG: hsa:25959

STRING: 9606.ENSP00000395650

UniGene: Hs.284208

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