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KCMF1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA873718LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KCMF1 Polyclonal antibody
Uniprot No.
Q9P0J7
Target Names
KCMF1
Alternative Names
KCMF1 antibody; FIGC antibody; ZZZ1 antibody; E3 ubiquitin-protein ligase KCMF1 antibody; EC 2.3.2.27 antibody; FGF-induced in gastric cancer antibody; Potassium channel modulatory factor antibody; PCMF antibody; RING-type E3 ubiquitin transferase KCMF1 antibody; ZZ-type zinc finger-containing protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase KCMF1 protein (98-226AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
Gene References into Functions
  1. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4. PMID: 25582440
  2. Data indicate that expressions of miR-210 and potassium channel modulatory factor 1 (KCMF1) exhibited an inverse correlation in placentas from patients with severe preeclampsia. PMID: 24980667
  3. Data indicate that FIGC upregulation in response to basic fibroblast growth factor in gastric cancer might be implicated in carcinogenesis through dysregulation of growth modulator. PMID: 15581609
  4. Suppression of KCMF1 by constitutive high CD99 expression levels contribute to the malignant properties of Ewing's sarcoma by promoting growth and migration of tumor cells PMID: 16314831
Protein Families
KCMF1 family
Tissue Specificity
Spleen, small intestine, ovary, peripheral blood, lung, kidney and pancreas. Expressed at low levels in the thymus, prostate, testis, colon, heart, brain, placenta and liver.
Database Links

HGNC: 20589

OMIM: 614719

KEGG: hsa:56888

STRING: 9606.ENSP00000386738

UniGene: Hs.654968

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