KCNIP4 Antibody

Datasheet

Code	CSB-PA750882LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA750882LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA750882LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KCNIP4 Polyclonal antibody

Uniprot No.

Q6PIL6

Target Names

KCNIP4

Alternative Names

A type potassium channel modulatory protein 4 antibody; A-type potassium channel modulatory protein 4 antibody; CALP antibody; Calsenilin like protein antibody; Calsenilin-like protein antibody; HGNC:30083 antibody; KCHIP 4 antibody; KChIP4 antibody; KCIP4_HUMAN antibody; KCNIP 4 antibody; Kcnip4 antibody; Kv channel interacting protein 4 antibody; Kv channel-interacting protein 4 antibody; MGC44947 antibody; Potassium channel interacting protein 4 antibody; Potassium channel-interacting protein 4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kv channel-interacting protein 4 protein (1-250AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The KCNIP4 Antibody (Product code: CSB-PA750882LA01HU) is Non-conjugated. For KCNIP4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA750882LB01HU	KCNIP4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA750882LC01HU	KCNIP4 Antibody, FITC conjugated
Biotin	CSB-PA750882LD01HU	KCNIP4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.

Gene References into Functions

Results indicate that SNPs in KCNIP4 may modulate ACE inhibitor-induced cough risk. PMID: 26169577
Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4. PMID: 24811166
genetic association studies in populations in Germany: Data suggest that multiple SNPs in KCNIP4 are associated not only with attention deficit disorder with hyperactivity in children and adults but also with personality disorders. PMID: 22981920
Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse. PMID: 23457522
KChIP4a suppresses A-type Kv4 current via ER retention and enhancement of Kv4 closed-state inactivation. PMID: 23576435
The synthesis of the variant KCNIP4 isoform is also detrimental to brain physiology, as it results in the concomitant blockade of the fast kinetics of potassium channels. PMID: 21624954
These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a. PMID: 20045463
cloning and investigation of interaction with presenilin 2 and voltage-gated potassium channel subunit Kv4 PMID: 11847232
The conformational change with metal-bound KChIP4.1 is crucial for its interaction with Kv channel but not for KChIP2.2, and that the Mg2+- and Ca2+-binding properties of KChIP2.2 and KChIP4.1 have different effects on their molecular structure. PMID: 16951992
Mutation of KCNIP4 is associated with renal cell carcinoma. PMID: 17981209
CALP and calsenilin are involved in the trafficking of Golgi glycosyltransferases. PMID: 18269347
These results reveal a new role for KChIP3 in the regulation of calcium regulated secretion and also suggest that the functions of each of the KChIPs may be more specialized than previously appreciated. PMID: 18393943
KChIP4a, KChIP2x, and KChIP3x comprise a novel class of KChIP isoforms characterized by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and trafficking. PMID: 18957440

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Subcellular Location

Cell membrane; Peripheral membrane protein. Cytoplasm.; [Isoform 4]: Endoplasmic reticulum.

Protein Families

Recoverin family

Tissue Specificity

Predominantly expressed in brain.

Database Links

HGNC: 30083

OMIM: 608182

KEGG: hsa:80333

STRING: 9606.ENSP00000371587

UniGene: Hs.655705

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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